A predictive model for MGMT promoter methylation status in glioblastoma based on terahertz spectral data

被引：0
作者：
Du, Minghui [1 ,2 ]
Wu, Xianhao [3 ]
Sun, Zhiyan [1 ,2 ]
Tao, Rui [1 ,2 ]
Sun, Peiyuan [1 ,2 ]
Zheng, Shaowen [3 ]
Zhang, Zhaohui [3 ,5 ]
Zhang, Tianyao [3 ]
Zhao, Xiaoyan [3 ,4 ]
Yang, Pei [1 ,2 ]
机构：
[1] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China
[2] Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R China
[3] Univ Sci & Technol Beijing, Sch Automat & Elect Engn, Beijing, Peoples R China
[4] Univ Sci & Technol Beijing, Beijing Engn Res Ctr Ind Spectrum Imaging, Sch Automat & Elect Engn, Beijing, Peoples R China
[5] Univ Sci & Technol Beijing, Shunde Innovat Sch, Foshan, Peoples R China
来源：
ANALYTICAL BIOCHEMISTRY | 2025年 / 702卷
关键词：
Terahertz; Glioblastoma; MGMT; Predictive modeling; CENTRAL-NERVOUS-SYSTEM; BIOMEDICAL APPLICATIONS; TEMOZOLOMIDE; GLIOMAS;
D O I：
10.1016/j.ab.2025.115850
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation is a crucial biomarker in glioblastoma (GBM) that influences response to temozolomide. Traditional detection methods, such as gene sequencing, are time-consuming and limited to postoperative analysis. This study explores the use of terahertz time-domain spectroscopy (THz-TDS) combined with machine learning to predict MGMT methylation status intraoperatively. By analyzing 180 GBM tissue samples, a Random Forest model was developed, achieving an AUC of 0.862. The findings suggest that THz spectroscopy offers a rapid, intraoperative alternative to traditional MGMT methylation detection methods, potentially enhancing surgical decision-making and personalized treatment strategies in GBM.
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页数：8
相关论文
共 36 条
  • [1] Emerging treatment strategies for glioblastoma multiforme
    Carlsson, Steven K.
    Brothers, Shaun P.
    Wahlestedt, Claes
    [J]. EMBO MOLECULAR MEDICINE, 2014, 6 (11) : 1359 - 1370
  • [2] Resveratrol Reduces the Invasive Growth and Promotes the Acquisition of a Long-Lasting Differentiated Phenotype in Human Glioblastoma Cells
    Castino, Roberta
    Pucer, Anja
    Veneroni, Roberta
    Morani, Federica
    Peracchio, Claudia
    Lah, Tamara T.
    Isidoro, Ciro
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 59 (08) : 4264 - 4272
  • [3] Performance of THz fiber-scanning near-field microscopy to diagnose breast tumors
    Chen, Hua
    Lee, Wen-Jeng
    Huang, Hsin-Yi
    Chiu, Chui-Min
    Tsai, Yuan-Fu
    Tseng, Tzu-Fang
    Lu, Jen-Tang
    Lai, Wei-Ling
    Sun, Chi-Kuang
    [J]. OPTICS EXPRESS, 2011, 19 (20): : 19523 - 19531
  • [4] Detection and manipulation of methylation in blood cancer DNA using terahertz radiation
    Cheon, Hwayeong
    Paik, Jin Ho
    Choi, Moran
    Yang, Hee-Jin
    Son, Joo-Hiuk
    [J]. SCIENTIFIC REPORTS, 2019, 9 (1)
  • [5] Terahertz Time-Domain Spectroscopy of Glioma Patient Blood Plasma: Diagnosis and Treatment
    Cherkasova, Olga
    Vrazhnov, Denis
    Knyazkova, Anastasia
    Konnikova, Maria
    Stupak, Evgeny
    Glotov, Vadim
    Stupak, Vyacheslav
    Nikolaev, Nazar
    Paulish, Andrey
    Peng, Yan
    Kistenev, Yury
    Shkurinov, Alexander
    [J]. APPLIED SCIENCES-BASEL, 2023, 13 (09):
  • [6] de Matos LL, 2010, BIOMARK INSIGHTS, V5, P9
  • [7] Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
    Esteller, M
    Garcia-Foncillas, J
    Andion, E
    Goodman, SN
    Hidalgo, OF
    Vanaclocha, V
    Baylin, SB
    Herman, JG
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (19) : 1350 - 1354
  • [8] Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis
    Gavdush, Arseniy A.
    Chernomyrdin, Nikita, V
    Malakhov, Kirill M.
    Beshplav, Sheyh-Islyam T.
    Dolganova, Irina N.
    Kosyrkova, Alexandra, V
    Nikitin, Pavel, V
    Musina, Guzel R.
    Katyba, Gleb M.
    Reshetov, Igor, V
    Cherkasova, Olga P.
    Komandin, Gennady A.
    Karasik, Valery E.
    Potapov, Alexander A.
    Tuchin, Valery V.
    Zaytsev, Kirill, I
    [J]. JOURNAL OF BIOMEDICAL OPTICS, 2019, 24 (02)
  • [9] Advances in terahertz technology for cancer detection applications
    Gezimati, Mavis
    Singh, Ghanshyam
    [J]. OPTICAL AND QUANTUM ELECTRONICS, 2023, 55 (02)
  • [10] Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial
    Gilbert, Mark R.
    Wang, Meihua
    Aldape, Kenneth D.
    Stupp, Roger
    Hegi, Monika E.
    Jaeckle, Kurt A.
    Armstrong, Terri S.
    Wefel, Jeffrey S.
    Won, Minhee
    Blumenthal, Deborah T.
    Mahajan, Anita
    Schultz, Christopher J.
    Erridge, Sara
    Baumert, Brigitta
    Hopkins, Kristen I.
    Tzuk-Shina, Tzahala
    Brown, Paul D.
    Chakravarti, Arnab
    Curran, Walter J., Jr.
    Mehta, Minesh P.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (32) : 4085 - +
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