Beyond tumor-associated macrophages involved in spheroid formation and dissemination: Novel insights for ovarian cancer therapy (Review)

被引：1
作者：
Liu, Yuchen [1 ]
Xiao, Haoyue [1 ]
Zeng, Hai [2 ]
Xiang, Ying [1 ,3 ]
机构：
[1] Yangtze Univ, Sch Basic Med, Ctr Mol Med, Lab Oncol,Hlth Sci Ctr, 1 Nanhuan Rd, Jingzhou 434023, Hubei, Peoples R China
[2] Yangtze Univ, Affiliated Hosp 1, Dept Oncol, 8 Hang Kong Rd, Jingzhou 434023, Hubei, Peoples R China
[3] Yangtze Univ, Hlth Sci Ctr, Sch Basic Med, Dept Cell Biol & Genet, Jingzhou 434023, Hubei, Peoples R China
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 2024年 / 65卷 / 06期
基金：
中国国家自然科学基金;
关键词：
ovarian cancer; tumor-associated macrophage; spheroid; peritoneal metastasis; ENDOTHELIAL GROWTH-FACTOR; ANOIKIS RESISTANCE; EXTRACELLULAR-MATRIX; STEM-CELLS; MULTICELLULAR SPHEROIDS; INDUCED PROLIFERATION; MOLECULAR-MECHANISMS; CADHERIN EXPRESSION; CARCINOMA-CELLS; IN-VITRO;
D O I：
10.3892/ijo.2024.5705
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ovarian cancer (OC) is the most common and deadly malignant tumor of the female reproductive system. When OC cells detach from the primary tumor and enter the ascitic microenvironment, they are present as individual cells or multicellular spheroids in ascites. These spheroids, composed of cancer and non-malignant cells, are metastatic units and play a crucial role in the progression of OC. However, little is known about the mechanism of spheroid formation and dissemination. Tumor-associated macrophages (TAMs) in the center of spheroids are key in spheroid formation and metastasis and provide a potential target for OC therapy. The present review summarizes the key biological features of spheroids, focusing on the role of TAMs in spheroid formation, survival and peritoneal metastasis, and the strategies targeting TAMs to provide new insights in treating OC.
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页数：17
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