Microfluidic technologies for cell deformability cytometry

被引：57
作者：
Chen, Hanxu [1 ]
Guo, Jiahui [1 ]
Bian, Feika [1 ]
Zhao, Yuanjin [1 ,2 ]
机构：
[1] Southeast Univ, Nanjing Drum Tower Hosp, Sch Biol Sci & Med Engn, Dept Clin Lab, Nanjing 210096, Jiangsu, Peoples R China
[2] Univ Chinese Acad Sci, Wenzhou Inst, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Oujiang Lab, Wenzhou, Zhejiang, Peoples R China
来源：
SMART MEDICINE | 2022年 / 1卷 / 01期
基金：
中国国家自然科学基金;
关键词：
biomechanical; deformability cytometry; high-throughput; microfluidic; single-cell;
D O I：
10.1002/SMMD.20220001
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Microfluidic detection methods for cell deformability cytometry have been regarded as powerful tools for single-cell analysis of cellular mechanical phenotypes, thus having been widely applied in the fields of cell preparation, separation, clinical diagnostics and so on. Featured with traits like easy operations, low cost and high throughput, such methods have shown great potentials on investigating physiological state and pathological changes during cellular deformation. Herein, a review on the advancements of microfluidic-based cell deformation cytometry is presented. We discuss several representative microfluidic-based cell deformability cytometry methods with their frontiers in practical applications. Finally, we analyze the current status and propose the remaining challenges with future perspectives and development directions.
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页数：12
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