Curcumin-loaded pickering emulsions based on soy protein isolate aggregates enhance diabetic wound healing

被引：0
作者：
Hosseini, Soroush Behjati [1 ]
Arghavani, Payam [1 ]
Hong, Jun [2 ]
Rahimi, Hamid Reza [3 ]
Azad-Armaki, Saeed [4 ]
Yousefi, Reza [1 ]
Moosavi-Movahedi, Ali Akbar [1 ]
机构：
[1] Univ Tehran, Inst Biochem & Biophys IBB, Tehran, Iran
[2] Henan Univ, Sch Life Sci, Kaifeng, Peoples R China
[3] Mashhad Univ Med Sci, Med Genet Res Ctr, Mashhad, Iran
[4] Khatamolanbia Hosp, Clin Lab Sect, Tehran, Iran
来源：
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2024年 / 101卷
基金：
中国国家自然科学基金; 美国国家科学基金会;
关键词：
Soy protein isolate (SPI); Pickering emulsion; Protein aggregation; Curcumin; Diabetic wound; NANOPARTICLES; HYDROGEL; STABILITY; HEAT;
D O I：
10.1016/j.jddst.2024.106279
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Wound healing in diabetic patients is more complex and prolonged in comparison to nondiabetic persons, and dealing with this problem has attracted considerable attention from researchers. According to its antiinflammatory and anti-infective properties, Curcumin has a valued place in therapeutics, including wound healing. Still, its low stability and poor bioavailability are significant barriers to using its desirable properties. Hence, various biocompatible and biodegradable delivery systems have been developed to address this issue. In this study, Pickering emulsion (PE) prepared from soybean oil containing curcumin and modified SPI solution at 85 degrees C at pH 2.0 with 130 mM NaCl for different durations were used as a delivery system for curcumin. Changes in SPI properties were analyzed using fluorescence spectroscopy, Fourier transform infrared spectroscopy, and tensiometry methods. The prepared PEs were studied using microscopic techniques. Curcumin loading efficiency by PE was measured by UV-visible spectroscopy, and the impact of curcumin-loaded PE on wound healing was tested in diabetic rats. Spectroscopic studies and microscopy images revealed SPI amyloid-like aggregates suitable for stabilizing oil-in-water PEs. Tensiometry and creaming stability studies indicated that at least 6 h of heating (HSPI6) is necessary for optimal stability. Curcumin encapsulation efficiency was 95.7 +/- 2.1 %. Curcumin-loaded PE-HSPI6 increased the healing rate of diabetic wounds in male Wistar rats by 1.46-fold. This study presents an approach for using biocompatible and biodegradable PEs to deliver hydrophobic compounds like curcumin for accelerating diabetic wound healing.
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页数：11
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  • [1] Seo E., Lim J.S., Jun J.-B., Choi W., Hong I.-S., Jun H.-S., Exendin-4 in combination with adipose-derived stem cells promotes angiogenesis and improves diabetic wound healing, J. Transl. Med., 15, pp. 1-9, (2017)
  • [2] Spampinato S.F., Caruso G.I., De Pasquale R., Sortino M.A., Merlo S., The treatment of impaired wound healing in diabetes: looking among old drugs, Pharmaceuticals, 13, 4, (2020)
  • [3] Manjubaashini N., Bargavi P., Thomas N.G., Krishnan N., Balakumar S., Chitosan bioactive glass scaffolds for in vivo subcutaneous implantation, toxicity assessment, and diabetic wound healing upon animal model, Int. J. Biol. Macromol., 256, (2024)
  • [4] Shao Y., Dang M., Lin Y., Xue F., Evaluation of wound healing activity of plumbagin in diabetic rats, Life Sci., 231, (2019)
  • [5] Rezvanian M., Ng S.-F., Alavi T., Ahmad W., In-vivo evaluation of Alginate-Pectin hydrogel film loaded with Simvastatin for diabetic wound healing in Streptozotocin-induced diabetic rats, Int. J. Biol. Macromol., 171, pp. 308-319, (2021)
  • [6] Alven S., Peter S., Mbese Z., Aderibigbe B.A., Polymer-based wound dressing materials loaded with bioactive agents: potential materials for the treatment of diabetic wounds, Polymers, 14, 4, (2022)
  • [7] Wang H., Xu Z., Zhao M., Liu G., Wu J., Advances of hydrogel dressings in diabetic wounds, Biomater. Sci., 9, 5, pp. 1530-1546, (2021)
  • [8] Tan C., McClements D.J., Application of advanced emulsion technology in the food industry: a review and critical evaluation, Foods, 10, 4, (2021)
  • [9] Tai Z., Huang Y., Zhu Q., Wu W., Yi T., Chen Z., Lu Y., Utility of Pickering emulsions in improved oral drug delivery, Drug Discov. Today, 25, 11, pp. 2038-2045, (2020)
  • [10] Jalilian R., Shahmari M., Taheri A., Gholami K., Ultrasonic-assisted micro solid phase extraction of arsenic on a new ion-imprinted polymer synthesized from chitosan-stabilized pickering emulsion in water, rice and vegetable samples, Ultrason. Sonochem., 61, (2020)
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