Prognostic Significance of the Combined Albumin-To-Alkaline Phosphatase Ratio (AAPR) and Haemoglobin-Albumin-Lymphocyte-Platelet (HALP) Score in Patients with Metastatic Renal Cell Carcinoma Treated by Targeted Therapy: A New Prognostic Combined Risk Scoring

被引:0
作者
Koseci, Tolga [1 ]
Seyyar, Mustafa [2 ]
Kidi, Mehmet Mutlu [1 ]
Biter, Sedat [1 ]
Eser, Kadir [3 ]
Kefeli, Umut [4 ]
Nayir, Erdinc [5 ]
Duman, Berna Bozkurt [6 ]
Mete, Burak [7 ]
Demirhindi, Hakan [7 ]
Cil, Timucin [6 ]
机构
[1] Cukurova Univ, Fac Med, Dept Med Oncol, TR-01330 Adana, Turkiye
[2] Gaziantep City Hosp, Dept Med Oncol, TR-27010 Gaziantep, Turkiye
[3] Mersin Univ Hosp, Dept Oncol, TR-33240 Mersin, Turkiye
[4] Kocaeli Univ, Fac Med, Dept Med Oncol, TR-41001 Kocaeli, Turkiye
[5] Mersin Med Pk Hosp, Dept Med Oncol, TR-33200 Mersin, Turkiye
[6] Univ Hlth Sci, Adana City Training & Res Hosp, Dept Med Oncol, TR-01370 Adana, Turkiye
[7] Cukurova Univ, Fac Med, Dept Publ Hlth, TR-01330 Adana, Turkiye
关键词
renal cell carcinoma; tyrosine kinase inhibitors; AAPR; HALP; prognosis; INFLAMMATION; CANCER; SURVIVAL; PAZOPANIB; OUTCOMES; HYPOXIA; ANEMIA;
D O I
10.3390/jcm14051742
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background/Objectives: Renal cell carcinoma (RCC) accounts for 2-3% of all cancers, with approximately 25% of patients being detected at the metastatic stage. This study aimed to determine the prognostic significance of co-evaluating two risk parameters: one, the HALP score based on haemoglobin, albumin, lymphocyte, and platelet counts, and the other, albumin-to-alkaline phosphatase ratio (AAPR) in patients with metastatic RCC treated with targeted therapy. Methods: This retrospective cohort study included 147 patients with metastatic RCC. The HALP score and AAPR values were calculated from pre-treatment blood test results, and followingly, the cut-off value was determined by using ROC analysis. Patients were categorised into three groups with a low, moderate or high combined risk score based on this cut-off value. The effect of these risk groups on survival was evaluated. Results: The mean age of patients was 64.1 +/- 11.9. The median follow-up time was 38.3 months, and the mortality rate was 53.7% in all groups. Kaplan-Meier survival analysis showed a statistically significant difference between the combined scores of the risk groups: the median survival time was 51.6 months in the low-risk group, 20.7 months in the medium-risk group, and 10.4 months in the high-risk group (p < 0.001), with 5-year survival rates being 38.8% in the low-risk group, 30% in the intermediate-risk group, and 19% in the high-risk group. When compared to the low-risk group, Cox regression analysis revealed that the mortality risk, i.e., HR (hazard ratio), was 2.42 times higher in the intermediate-risk group and 3.76 times higher in the high-risk group. A nephrectomy operation decreased the mortality risk (HR = 0.24) by 4.16 times. Conclusions: This new combined risk scoring, obtained from co-evaluating the HALP score and AAPR, was found to be an independent prognostic factor in metastatic RCC patients. This combined risk scoring is expected to help clinicians in treatment decisions.
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页数:12
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