Hyaluronic Acid-Based Self-Healing Hydrogels for Diabetic Wound Healing

被引:2
作者
Chhillar, Anish [1 ]
Jaiswal, Amit [1 ]
机构
[1] Indian Inst Technol Mandi, Sch Biosci & Bioengn, Mandi 175075, Himachal Prades, India
关键词
diabetic wounds; hyaluronic acid; hydrogel; self-healing; wound healing; ANTIBACTERIAL ACTIVITY; ALGINATE HYDROGEL; STEM-CELLS; FOOT; RELEASE; NANOPARTICLES; ADHESIVE; SYSTEM; UV;
D O I
10.1002/adhm.202404255
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Diabetic wounds, particularly diabetic foot ulcers (DFUs), are significant threats to human well-being due to their impaired healing from poor circulation and high blood sugar, increased risk of infection and potential for severe complications like amputation, all compounded by peripheral neuropathy and chronic inflammation. Most therapies and dressings for DFUs focus on one symptom at a time, however, multifunctional smart self-healing hydrogels can withstand multifactorial motional diabetic wounds. Motional wounds are easy-to-split wounds that experience tension, compression, and movement caused by stress now and then. Hyaluronic acid (HA) based self-healing hydrogels stand out among other biomaterials due to their ability to cover irregular wound surfaces, maintain a moist environment, repair themselves when ruptured, and exhibit excellent biocompatibility. These self-healing hydrogels can repair damages caused by movement and recover the functional properties during healing. These hydrogels can also act as therapeutic delivery vehicles and tissue regeneration systems. This review demonstrates the potential of HA-based self-healing hydrogels for diabetic wound healing. Due to its self-healing capabilities, these hydrogels offer a customized therapeutic approach for motional diabetic wounds. The review also critically examines the challenges and future directions for HA-based self-healing hydrogels in diabetic wound healing.
引用
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页数:18
相关论文
共 130 条
[91]   Ros-responsive hydrogel with size-dependent sequential release effects for anti-bacterial and anti-inflammation in diabetic wound healing [J].
Sun, Zhipeng ;
Ding, Yilin ;
Wang, Zetao ;
Luo, Huitong ;
Feng, Qi ;
Cao, Xiaodong .
CHEMICAL ENGINEERING JOURNAL, 2024, 493
[92]  
Syauta D., 2021, MEDICINA CLINICA PRA, V4, DOI [10.1016/j.mcpsp.2021.100231, DOI 10.1016/J.MCPSP.2021.100231]
[93]   Biocompatible, Injectable, and Self-Healing Poly(N-vinylpyrrolidone)/Carboxymethyl Cellulose Hydrogel for Drug Release [J].
Tang, Zuwu ;
Yang, Yuqing ;
Pan, Yuwei ;
Yu, Meiqiong ;
Lin, Xinxing ;
Mondal, Ajoy Kanti .
ACS OMEGA, 2024, 9 (05) :5854-5861
[94]   Off-loading and compression therapy strategies to treat diabetic foot ulcers complicated by lower limb oedema: a scoping review [J].
Tansley, Justine ;
Collings, Richard ;
Williams, Jennifer ;
Paton, Joanne .
JOURNAL OF FOOT AND ANKLE RESEARCH, 2023, 16 (01)
[95]   Does Aggressive Glycemic Control Benefit Macrovascular and Microvascular Disease in Type 2 Diabetes?: Insights from ACCORD, ADVANCE, and VADT [J].
Terry, Toni ;
Raravikar, Kalyani ;
Chokrungvaranon, Nalurporn ;
Reaven, Peter D. .
CURRENT CARDIOLOGY REPORTS, 2012, 14 (01) :79-88
[96]   The influence of adequate debridement and placental-derived allografts on diabetic foot ulcers [J].
Tettelbach, William H. ;
Cazzell, Shawn M. ;
Hubbs, Brandon ;
De Jong, Julie L. ;
Forsyth, R. Allyn ;
Reyzelman, Alexander M. .
JOURNAL OF WOUND CARE, 2022, 31 (09) :S16-S26
[97]   A flexible, robust cellulose/phytic acid/polyaniline hydrogel for all-in-one supercapacitors and strain sensors [J].
Wan, Huixiong ;
Qin, Chaoran ;
Lu, Ang .
JOURNAL OF MATERIALS CHEMISTRY A, 2022, 10 (33) :17279-17287
[98]   Multiple Crosslinking Hyaluronic Acid Hydrogels with Improved Strength and 3D Printability [J].
Wan, Tingting ;
Fan, Penghui ;
Zhang, Mengfan ;
Shi, Kai ;
Chen, Xiao ;
Yang, Hongjun ;
Liu, Xin ;
Xu, Weilin ;
Zhou, Yingshan .
ACS APPLIED BIO MATERIALS, 2022, 5 (01) :334-343
[99]   A mace-like heterostructural enriched injectable hydrogel composite for on-demand promotion of diabetic wound healing [J].
Wang, Li ;
Hussain, Zahid ;
Zheng, Penghui ;
Zhang, Yajie ;
Cao, Yi ;
Gao, Tong ;
Zhang, Zhuangzhuang ;
Zhang, Yuehu ;
Pei, Renjun .
JOURNAL OF MATERIALS CHEMISTRY B, 2023, 11 (10) :2166-2183
[100]   Self-Adhesive, Strong Antifouling, and Mechanically Reinforced Methacrylate Hyaluronic Acid Cross-Linked Carboxybetaine Zwitterionic Hydrogels [J].
Wang, Shuaibing ;
Ren, Kai ;
Zhang, Miao ;
Shen, Luxuan ;
Zhou, Guangwu ;
Ding, Yuan ;
Xin, Qiangwei ;
Luo, Jun ;
Xie, Jing ;
Li, Jianshu .
BIOMACROMOLECULES, 2023, 25 (01) :474-485