Perioperative Considerations of Novel Antidiabetic Agents in Heart Failure Patients Undergoing Cardiac Surgery

被引:0
|
作者
Wang, Ashley [1 ]
Bitzas, Savannah [2 ]
Perez, Dilsa [2 ]
Schwartz, Jonathon [1 ]
Zaidi, Saleem [1 ]
Oster, Jonathan [1 ]
Bergese, Sergio D. [1 ]
机构
[1] Stony Brook Univ Hosp, Dept Anesthesiol, Stony Brook, NY 11794 USA
[2] SUNY Stony Brook, Renaissance Sch Med, Stony Brook, NY 11794 USA
来源
LIFE-BASEL | 2025年 / 15卷 / 03期
关键词
diabetes mellitus; heart failure; GLP-1 receptor agonist; DPP-4; inhibitors; SGLT2; cardiac surgery; cardiovascular disease; glycemic control; perioperative management; RECEPTOR AGONISTS; EJECTION FRACTION; DIABETES-MELLITUS; SGLT-2; INHIBITORS; AMERICAN-COLLEGE; GLUCOSE; ASSOCIATION; METAANALYSIS; MANAGEMENT; INSULIN;
D O I
10.3390/life15030427
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Diabetes mellitus (DM) is a major risk factor for cardiovascular disease, including heart failure (HF). A high proportion of DM patients eventually require cardiac surgery. While the traditional approach to DM therapy focuses on tight glucose control with insulin and oral hypoglycemic agents, novel antidiabetic drugs have emerged over the past two decades that offer not only improved glycemic control but also cardiovascular and renal protection, such as benefits in HF management. The aim of this review is to examine and evaluate the perioperative risk and benefits of novel antidiabetic agents in HF treatment for both DM and non-DM patients undergoing cardiac surgery. We specifically studied glucagon-like peptide-1 receptor agonists (GLP-1RAs), dipeptidyl peptidase-4 (DPP-4) inhibitors, and sodium-glucose cotransporter 2 inhibitors (SGLT2is). Although studies on novel antidiabetic therapy in cardiac surgeries were limited, the results showed all three agents to be safe for use in the perioperative period, with SLGT2i demonstrating the most benefits in HF management for those with or without DM and kidney impairment undergoing cardiac surgery. Future research on larger study populations and using a more rigorous study design is necessary in bridging current knowledge to improve patient outcomes.
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页数:23
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