Diabetes mellitus (DM) is a major risk factor for cardiovascular disease, including heart failure (HF). A high proportion of DM patients eventually require cardiac surgery. While the traditional approach to DM therapy focuses on tight glucose control with insulin and oral hypoglycemic agents, novel antidiabetic drugs have emerged over the past two decades that offer not only improved glycemic control but also cardiovascular and renal protection, such as benefits in HF management. The aim of this review is to examine and evaluate the perioperative risk and benefits of novel antidiabetic agents in HF treatment for both DM and non-DM patients undergoing cardiac surgery. We specifically studied glucagon-like peptide-1 receptor agonists (GLP-1RAs), dipeptidyl peptidase-4 (DPP-4) inhibitors, and sodium-glucose cotransporter 2 inhibitors (SGLT2is). Although studies on novel antidiabetic therapy in cardiac surgeries were limited, the results showed all three agents to be safe for use in the perioperative period, with SLGT2i demonstrating the most benefits in HF management for those with or without DM and kidney impairment undergoing cardiac surgery. Future research on larger study populations and using a more rigorous study design is necessary in bridging current knowledge to improve patient outcomes.
机构:
Mayo Clin, Dept Anesthesiol & Perioperat Med, Coll Med & Sci, 200 First St SW, Rochester, MN 55905 USAMayo Clin, Dept Anesthesiol & Perioperat Med, Coll Med & Sci, 200 First St SW, Rochester, MN 55905 USA
Klompas, Allan M.
Boswell, Michael R.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Anesthesiol & Perioperat Med, Coll Med & Sci, 200 First St SW, Rochester, MN 55905 USAMayo Clin, Dept Anesthesiol & Perioperat Med, Coll Med & Sci, 200 First St SW, Rochester, MN 55905 USA
Boswell, Michael R.
Plack, Daniel L.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Anesthesiol & Perioperat Med, Coll Med & Sci, 200 First St SW, Rochester, MN 55905 USAMayo Clin, Dept Anesthesiol & Perioperat Med, Coll Med & Sci, 200 First St SW, Rochester, MN 55905 USA
Plack, Daniel L.
Smith, Mark M.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Anesthesiol & Perioperat Med, Coll Med & Sci, 200 First St SW, Rochester, MN 55905 USAMayo Clin, Dept Anesthesiol & Perioperat Med, Coll Med & Sci, 200 First St SW, Rochester, MN 55905 USA
机构:
Mayo Clin, Coll Med & Sci, Dept Anesthesiol & Perioperat Med, 200 First St SW, Rochester, MN 55905 USAMayo Clin, Coll Med & Sci, Dept Anesthesiol & Perioperat Med, 200 First St SW, Rochester, MN 55905 USA
Smith, Bradford B.
Boswell, Michael R.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Coll Med & Sci, Dept Anesthesiol & Perioperat Med, 200 First St SW, Rochester, MN 55905 USAMayo Clin, Coll Med & Sci, Dept Anesthesiol & Perioperat Med, 200 First St SW, Rochester, MN 55905 USA
Boswell, Michael R.
Matzek, Luke J.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Coll Med & Sci, Dept Anesthesiol & Perioperat Med, 200 First St SW, Rochester, MN 55905 USAMayo Clin, Coll Med & Sci, Dept Anesthesiol & Perioperat Med, 200 First St SW, Rochester, MN 55905 USA
Matzek, Luke J.
Smith, Mark M.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Coll Med & Sci, Dept Anesthesiol & Perioperat Med, 200 First St SW, Rochester, MN 55905 USAMayo Clin, Coll Med & Sci, Dept Anesthesiol & Perioperat Med, 200 First St SW, Rochester, MN 55905 USA
机构:
Univ Western Ontario, Div Cardiol, Dept Med, London, ON N6A 5A5, CanadaUniv Western Ontario, Dept Anesthesia & Perioperat Med, London Hlth Sci Ctr, London, ON N6A 5A5, Canada
Lavi, Shahar
Lavi, Ronit
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Ontario, Dept Anesthesia & Perioperat Med, London Hlth Sci Ctr, London, ON N6A 5A5, CanadaUniv Western Ontario, Dept Anesthesia & Perioperat Med, London Hlth Sci Ctr, London, ON N6A 5A5, Canada
机构:
NYU, Dept Med, Leon H Charney Div Cardiol, Sch Med, 550 First Ave, New York, NY 10016 USA
Vet Affairs New York Harbor Hlth Care Syst, Div Cardiol, Dept Med, 423 East 23rd St,12W, New York, NY 10010 USANYU, Dept Med, Leon H Charney Div Cardiol, Sch Med, 550 First Ave, New York, NY 10016 USA
Smilowitz, Nathaniel R.
Banco, Darcy
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Dept Med, Leon H Charney Div Cardiol, Sch Med, 550 First Ave, New York, NY 10016 USANYU, Dept Med, Leon H Charney Div Cardiol, Sch Med, 550 First Ave, New York, NY 10016 USA
Banco, Darcy
Katz, Stuart D.
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Dept Med, Leon H Charney Div Cardiol, Sch Med, 550 First Ave, New York, NY 10016 USANYU, Dept Med, Leon H Charney Div Cardiol, Sch Med, 550 First Ave, New York, NY 10016 USA
Katz, Stuart D.
Beckman, Joshua A.
论文数: 0引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Dept Med, Sch Med, 1215 21st Ave South, Nashville, TN 37232 USANYU, Dept Med, Leon H Charney Div Cardiol, Sch Med, 550 First Ave, New York, NY 10016 USA
Beckman, Joshua A.
Berger, Jeffery S.
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Dept Med, Leon H Charney Div Cardiol, Sch Med, 550 First Ave, New York, NY 10016 USA
NYU, Dept Surg, Sch Med, 550 First Ave, New York, NY 10016 USANYU, Dept Med, Leon H Charney Div Cardiol, Sch Med, 550 First Ave, New York, NY 10016 USA
机构:
Mayo Clin, Coll Med & Sci, Dept Anesthesiol & Perioperat Med, 200 First St SW, Rochester, MN 55905 USAMayo Clin, Coll Med & Sci, Dept Anesthesiol & Perioperat Med, 200 First St SW, Rochester, MN 55905 USA
Smith, Mark M.
Renew, J. Ross
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Coll Med & Sci, Dept Anesthesiol & Perioperat Med, Jacksonville, FL 32224 USAMayo Clin, Coll Med & Sci, Dept Anesthesiol & Perioperat Med, 200 First St SW, Rochester, MN 55905 USA
Renew, J. Ross
Nelson, James A.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Coll Med & Sci, Dept Anesthesiol & Perioperat Med, 200 First St SW, Rochester, MN 55905 USAMayo Clin, Coll Med & Sci, Dept Anesthesiol & Perioperat Med, 200 First St SW, Rochester, MN 55905 USA
Nelson, James A.
Barbara, David W.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Coll Med & Sci, Dept Anesthesiol & Perioperat Med, 200 First St SW, Rochester, MN 55905 USAMayo Clin, Coll Med & Sci, Dept Anesthesiol & Perioperat Med, 200 First St SW, Rochester, MN 55905 USA