T-Type Voltage-Gated Calcium Channels: Potential Regulators of Smooth Muscle Contractility

被引:0
作者
Tomida, Shota [1 ,2 ]
Ishima, Tamaki [1 ]
Nagai, Ryozo [3 ]
Aizawa, Kenichi [1 ,4 ,5 ]
机构
[1] Jichi Med Univ, Dept Pharmacol, Div Clin Pharmacol, Shimotsuke 3290498, Japan
[2] Gunma Univ, Fac Med, Sch Med, Maebashi 3718511, Japan
[3] Jichi Med Univ, Shimotsuke 3290498, Japan
[4] Jichi Med Univ Hosp, Clin Pharmacol Ctr, Shimotsuke 3290498, Japan
[5] Jichi Med Univ Hosp, Clin Res Ctr, Div Translat Res, Shimotsuke 3290498, Japan
关键词
T-type voltage-gated calcium channel; smooth muscle contractility; multi-omics; CA2+ CHANNELS; AORTIC-ANEURYSMS; EXPRESSION; CA(V)3.1; INACTIVATION; ACTIVATION; GENE; PROLIFERATION; INHIBITION; CURRENTS;
D O I
10.3390/ijms252212420
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Emerging evidence has indicated a possible link between attenuation of contractility in aortic smooth muscle cells and pathogenesis of aortic dissection, as revealed through comprehensive, multi-omic analyses of familial thoracic aortic aneurysm and dissection models. While L-type voltage-gated calcium channels have been extensively investigated for their roles in smooth muscle contraction, more recent investigations have suggested that downregulation of T-type voltage-gated calcium channels, rather than their L-type counterparts, may be more closely associated with impaired contractility observed in vascular smooth muscle cells. This review provides a detailed examination of T-type voltage-gated calcium channels, highlighting their structure, electrophysiology, biophysics, expression patterns, functional roles, and potential mechanisms through which their downregulation may contribute to reduced contractile function. Furthermore, the application of multi-omic approaches in investigating calcium channels is discussed.
引用
收藏
页数:14
相关论文
共 107 条
  • [1] Identification of L- and T-type Ca2+ channels in rat cerebral arteries: role in myogenic tone development
    Abd El-Rahman, Rasha R.
    Harraz, Osama F.
    Brett, Suzanne E.
    Anfinogenova, Yana
    Mufti, Rania E.
    Goldman, Daniel
    Welsh, Donald G.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2013, 304 (01): : H58 - H71
  • [2] Ahmed S., 2021, Curr. Cardiol. Rev, V17, P12
  • [3] Cav3.2 T-Type Calcium Channel Mediates Acute Itch and Contributes to Chronic Itch and Inflammation in Experimental Atopic Dermatitis
    Ahn, Ji-Woong
    Kim, Song-Ee
    Kim, Do-Young
    Jeong, Inhye
    Kim, Sohyun
    Chung, Seungsoo
    Lee, Sang Eun
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2024, 144 (03) : 612 - 620.e6
  • [4] ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle
    Akin, Elizabeth J.
    Aoun, Joydeep
    Jimenez, Connor
    Mayne, Katie
    Baeck, Julius
    Young, Michael D.
    Sullivan, Brennan
    Sanders, Kenton M.
    Ward, Sean M.
    Bulley, Simon
    Jaggar, Jonathan H.
    Earley, Scott
    Greenwood, Iain A.
    Leblanc, Normand
    [J]. JOURNAL OF GENERAL PHYSIOLOGY, 2023, 155 (11)
  • [5] Coexpression of voltage-dependent calcium channels CaV1.2, 2.1a, and 2.1b in vascular myocytes
    Andreasen, D
    Friis, UG
    Uhrenholt, TR
    Jensen, BL
    Skott, O
    Hansen, PB
    [J]. HYPERTENSION, 2006, 47 (04) : 735 - 741
  • [6] The T-type Calcium Channel Cav3.1 in Y79 Retinoblastoma Cells is Regulated by the Epidermal Growth Factor Receptor via the MAPK Signaling Pathway
    Banderali, Umberto
    Jain, Mohit
    Thakur, Satbir
    Jayanthan, Aarthi
    Belke, Darrell D.
    Giles, Wayne R.
    Narendran, Aru
    [J]. CURRENT EYE RESEARCH, 2022, 47 (03) : 426 - 435
  • [7] I-II Loop Structural Determinants in the Gating and Surface Expression of Low Voltage-Activated Calcium Channels
    Baumgart, Joel P.
    Vitko, Iuliia
    Bidaud, Isabelle
    Kondratskyi, Artem
    Lory, Philippe
    Perez-Reyes, Edward
    [J]. PLOS ONE, 2008, 3 (08):
  • [8] Regulation of α1G T-type calcium channel gene (CACNA1G) expression during neuronal differentiation
    Bertolesi, GE
    Jollimore, CAB
    Shi, CJ
    Elbaum, L
    Denovan-Wright, EM
    Barnes, S
    Kelly, MEM
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 17 (09) : 1802 - 1810
  • [9] Interleukin-22 receptor 1-mediated stimulation of T-type Ca2+ channels enhances sensory neuronal excitability through the tyrosine-protein kinase Lyn-dependent PKA pathway
    Cai, Hua
    Chen, Siyu
    Sun, Yufang
    Zheng, Tingting
    Liu, Yulu
    Tao, Jin
    Zhang, Yuan
    [J]. CELL COMMUNICATION AND SIGNALING, 2024, 22 (01)
  • [10] Transcriptional Regulators of T Helper 17 Cell Differentiation in Health and Autoimmune Diseases
    Capone, Alessia
    Volpe, Elisabetta
    [J]. FRONTIERS IN IMMUNOLOGY, 2020, 11