Neuroimmune interactions between itch neurons and skin microbes

被引：0
|
作者：
Balaji, Sharan Kumar [1 ]
Khuwaja, Waris Muhammad [1 ]
Hossain, Md Liakat [1 ]
Fernando, Luchiano Giovanni Benjamin [1 ]
Dong, Xintong [1 ]
机构：
[1] Univ Texas Dallas, Dept Biol Sci, Richardson, TX 75080 USA
来源：
SEMINARS IN IMMUNOLOGY | 2025年 / 78卷
关键词：
Itch; Microbiome; Atopic dermatitis; Cytokines; S; aureus; CATHELICIDIN ANTIMICROBIAL PEPTIDES; ATOPIC-DERMATITIS; SENSORY NEURONS; MAST-CELL; CONTACT HYPERSENSITIVITY; PROPIONIBACTERIUM-ACNES; ADAPTIVE IMMUNITY; SIGNAL TRANSDUCER; CANDIDA-ALBICANS; DENDRITIC CELLS;
D O I：
10.1016/j.smim.2025.101933
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Itch is an unpleasant sensation that is encoded by specific sensory neurons called pruriceptors. Itch is associated with almost all skin diseases. Recent studies revealed that many itchy skin diseases are associated with micro- biome dysbiosis. Pathogenic microbes secrete proteases and toxins to invade skin cells. Some microbial products can directly activate sensory neurons, while others activate the mammalian immune system and indirectly cause itch. In this review, we summarize the current knowledge on microbe-immune-neuron crosstalks and discuss their relevance in itchy skin diseases.
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页数：13
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