Salvage endoscopic nasopharyngectomy for recurrent nasopharyngeal carcinoma in a non-endemic area

被引：0

作者：

Valentini, Marco ^{[1
,3
]}

Lambertoni, Alessia ^{[2
]}

Sileo, Giorgio ^{[2
]}

Arosio, Alberto Daniele ^{[2
]}

Dalfino, Gianluca ^{[2
]}

Pedretti, Fabio ^{[4
]}

Karligkiotis, Apostolos ^{[2
]}

Bignami, Maurizio ^{[2
,3
]}

Battaglia, Paolo ^{[1
,3
]}

Castelnuovo, Paolo ^{[2
,3
]}

Turri-Zanoni, Mario ^{[1
,3
]}

机构：

[1] Univ Insubria, Dept Otolaryngol Head & Neck Surg, Dept Biotechnol & Life Sci, ASST Lariana,Osped St Anna, I-22042 Como, San Fermo Della, Italy

[2] Univ Insubria, Dept Otorhinolaryngol Head & Neck Surg, Dept Biotechnol & Life Sci, Osped Circolo & Fdn Macchi,ASST Sette Laghi, I-21100 Varese, Italy

[3] Univ Insubria, Dept Biotechnol & Life Sci, Head & Neck Surg & Forens Dissect Res Ctr HNS & F, I-21100 Varese, Italy

[4] Univ Pavia, Dept Otolaryngol, I-27100 Pavia, Italy

来源：

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 2024年 / 281卷 / 07期

关键词：

Endoscopic nasopharyngectomy; EBV; Nasopharyngeal carcinoma; Skull base; Head and neck oncology;

D O I：

暂无

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Purpose To analyze oncological outcomes of endoscopic surgical treatment of locally recurrent EBV-related undifferentiated non-keratinizing nasopharyngeal carcinoma (uNK-NPC) in a non-endemic area.Methods Retrospective review of patients affected by recurrent uNK-NPC treated with nasopharyngeal endoscopic resection (NER) in a tertiary-care referral center from 2003 to 2022, by evaluating survival rates, prognostic factors, and follow-up strategies.Results The oncological outcomes of 41 patients were analyzed, over a mean follow-up period of 57 months. The 5-year overall, disease-specific, and disease-free survival of the cohort were 60.7%8.9%, 69%+/- 9%, and 39.7%+/- 9.2%, respectively. The local (rT) and regional (rN) extension of recurrent disease, stage of disease, and status of resection margins appeared to significantly influence survivals. After a mean follow-up period of 21 months, a further recurrence after NER was observed in 36.6% of cases. Skull base osteonecrosis induced by previous irradiation and post-surgical bone remodeling represent the major challenges for early detection of further local relapses during postoperative follow-up.Conclusion NER appeared as a safe and effective treatment for recurrent uNK-NPC. The adequate selection of patients eligible for NER is essential, to maximize the chances to cure and minimize the risk of local complications.

引用

页码：3601 / 3613

页数：13