Emerging trends in early-onset gastric cancer

被引：0
作者：
Wang, Xinlin [1 ,2 ]
Gao, Xianchun [1 ,2 ]
Yu, Jun [1 ,2 ]
Zhang, Xiaotian [1 ,3 ]
Nie, Yongzhan [1 ,2 ]
机构：
[1] State Key Lab Holist Integrat Management Gastroint, Xian 710032, Shaanxi, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp Digest Dis, Natl Clin Res Ctr Digest Dis, Xian 710032, Shaanxi, Peoples R China
[3] Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Oncol, Beijing Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
来源：
CHINESE MEDICAL JOURNAL | 2024年 / 137卷 / 18期
基金：
中国国家自然科学基金;
关键词：
Early-onset gastric cancer; Epidemiology; Etiology; Clinicopathological features; Molecular signaling; Prognosis; Clinical management; HELICOBACTER-PYLORI INFECTION; YOUNG-PATIENTS; AGE; SURVIVAL; EFFICACY; DIFFUSE; DISEASE;
D O I：
10.1097/CM9.0000000000003259
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The incidence of early-onset gastric cancer (EOGC) is consistently increasing, and its etiology is notably complex. This increase may be attributed to distinctive factors that differ from those associated with late-onset gastric cancer (LOGC), including genetic predispositions, dietary factors, gastric microbiota dysbiosis, and screening of high-risk cases. These factors collectively contribute to the onset of cancer. EOGC significantly differs from LOGC in terms of clinicopathological and molecular characteristics. Moreover, multiple differences in prognosis and clinical management also exist. This study aimed to systematically review the latest research advancements in the epidemiological characteristics, etiological factors, clinicopathological and molecular features, prognosis, and treatment modalities of EOGC.
引用
收藏
页码：2146 / 2156
页数：11
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