Brucella mediates autophagy, inflammation, and apoptosis to escape host killing

被引：0
作者：
Qin, Yaqiong [1 ]
Zhou, Gengxu [1 ]
Jiao, Fengyuan [1 ]
Cheng, Chuan [1 ]
Meng, Chi [1 ]
Wang, Lingjie [1 ]
Wu, Shengping [1 ]
Fan, Cailiang [1 ,2 ]
Li, Jixiang [1 ]
Zhou, Bo [3 ]
Chu, Yuefeng [4 ]
Jiao, Hanwei [1 ]
机构：
[1] Southwest Univ, Coll Vet Med, Chongqing, Peoples R China
[2] Anim Epidem Prevent & Control Ctr Rongchang, Chongqing, Peoples R China
[3] Chinese Acad Agr Sci, Vet Res Inst, Changchun, Jilin, Peoples R China
[4] Lanzhou Univ, Chinese Acad Agr Sci, State Key Lab Anim Dis Control & Prevent, Coll Vet Med,Lanzhou Vet Res Inst, Lanzhou, Gansu, Peoples R China
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2024年 / 14卷
关键词：
<italic>Brucella</italic>; intracellular survival; autophagy; inflammation; apoptosis; IV SECRETION SYSTEM; ENDOPLASMIC-RETICULUM; INTRACELLULAR SURVIVAL; CELL-DEATH; ER STRESS; IN-VITRO; ABORTUS; PROTEIN; IDENTIFICATION; MELITENSIS;
D O I：
10.3389/fcimb.2024.1408407
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Brucellosis is a serious zoonosis caused by Brucella spp. infection, which not only seriously jeopardizes the health of humans and mammals, but also causes huge economic losses to the livestock industry. Brucella is a Gram-negative intracellular bacterium that relies primarily on its virulence factors and a variety of evolved survival strategies to replicate and proliferate within cells. Currently, the mechanisms of autophagy, inflammation, and apoptosis in Brucella-infected hosts are not fully understood and require further research and discussion. This review focuses on the relationship between Brucella and autophagy, inflammation, and apoptosis to provide the scientific basis for revealing the pathogenesis of Brucella.
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页数：16
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