Idiopathic multicentric Castleman disease developing after a diagnosis of sarcoidosis: A case report and literature review

被引：0

作者：

Muramatsu, Takumi ^{[1
]}

Kono, Masato ^{[1
]}

Ishige, Masaki ^{[1
]}

Saito, Takahiko ^{[1
]}

Higasa, Misato ^{[1
]}

Nihashi, Fumiya ^{[1
]}

Aono, Yuya ^{[1
]}

Katsumata, Mineo ^{[1
]}

Miwa, Hideki ^{[1
]}

Miki, Yoshihiro ^{[1
]}

Misaki, Taro ^{[3
]}

Otsuki, Yoshiro ^{[4
]}

Hashimoto, Dai ^{[1
]}

Enomoto, Noriyuki ^{[2
]}

Suda, Takafumi ^{[2
]}

Nakamura, Hidenori ^{[1
,5
]}

机构：

[1] Seirei Hamamatsu Gen Hosp, Dept Resp Med, Hamamatsu 4308558, Japan

[2] Hamamatsu Univ Sch Med, Dept Internal Med, Div 2, Hamamatsu 4313192, Japan

[3] Seirei Hamamatsu Gen Hosp, Dept Nephrol, Hamamatsu 4308558, Japan

[4] Seirei Hamamatsu Gen Hosp, Dept Pathol, Hamamatsu 4308558, Japan

[5] Nishiyama Hosp, Div Internal Med, Hamamatsu 4328001, Japan

来源：

RESPIRATORY MEDICINE CASE REPORTS | 2025年 / 54卷

关键词：

Idiopathic multicentric Castleman disease; Sarcoidosis; Tocilizumab; LYMPHOMA;

D O I：

10.1016/j.rmcr.2025.102188

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

A 72-year-old woman presented with an abnormal shadow on chest radiograph. She was histologically diagnosed with sarcoidosis 20 years previously, and prednisolone was initiated 8 years previously. Computed tomography revealed centrilobular micronodules and bronchovascular bundle thickening in both lungs with multicentric lymphadenopathies; multiple pulmonary nodular lesions appeared during prednisolone tapering. Laboratory findings included polyclonal hypergammaglobulinemia and elevated interleukin-6 levels. Surgical lung biopsy revealed marked lymphoplasmacytic infiltration with lymphoid aggregates. The patient tested negative for human herpesvirus-8 and clinically diagnosed with idiopathic multicentric Castleman disease. The coexistence of sarcoidosis and Castleman disease is rare; this case improved with additional tocilizumab treatment.

引用

页数：7