Multidrug-resistant hypervirulent Klebsiella pneumoniae: an evolving superbug

被引：1
作者：
Zheng, Yu [1 ]
Zhu, Xiaojue [1 ]
Ding, Chao [1 ]
Chu, Weiqiang [1 ]
Pang, Xiaoxiao [1 ]
Zhang, Ruxia [1 ]
Ma, Jiucheng [2 ]
Xu, Guoxin [1 ]
机构：
[1] Soochow Univ, Affiliated Zhangjiagang Hosp, Dept Clin Lab, 68 Jiyang West Rd, Suzhou, Jiangsu, Peoples R China
[2] Soochow Univ, Affiliated Zhangjiagang Hosp, Dept Burns & Plast Surg, Suzhou, Peoples R China
来源：
FUTURE MICROBIOLOGY | 2025年 / 20卷 / 06期
关键词：
Klebsiella pneumoniae; virulence factor; multidrug resistance; horizontal gene transfer; diagnostic microbiology; CARBAPENEM-RESISTANCE; MOLECULAR EPIDEMIOLOGY; BIOFILM FORMATION; VIRULENCE; AEROBACTIN; EMERGENCE; ENTEROBACTERALES; SALMOCHELIN; INFECTIONS; MECHANISMS;
D O I：
10.1080/17460913.2025.2482478
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-hvKP) combines high pathogenicity with multidrug resistance to become a new superbug. MDR-hvKP reports continue to emerge, shattering the perception that hypervirulent K. pneumoniae (hvKP) strains are antibiotic sensitive. Patients infected with MDR-hvKP strains have been reported in Asia, particularly China. Although hvKP can acquire drug resistance genes, MDR-hvKP seems to be more easily transformed from classical K. pneumoniae (cKP), which has a strong gene uptake ability. To better understand the biology of MDR-hvKP, this review discusses the virulence factors, resistance mechanisms, formation pathways, and identification of MDR-hvKP. Given their destructive and transmissible potential, continued surveillance of these organisms and enhanced control measures should be prioritized.
引用
收藏
页码：499 / 511
页数：13
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