Multidrug-resistant hypervirulent Klebsiella pneumoniae: an evolving superbug

被引：1

作者：

Zheng, Yu ^{[1
]}

Zhu, Xiaojue ^{[1
]}

Ding, Chao ^{[1
]}

Chu, Weiqiang ^{[1
]}

Pang, Xiaoxiao ^{[1
]}

Zhang, Ruxia ^{[1
]}

Ma, Jiucheng ^{[2
]}

Xu, Guoxin ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Zhangjiagang Hosp, Dept Clin Lab, 68 Jiyang West Rd, Suzhou, Jiangsu, Peoples R China

[2] Soochow Univ, Affiliated Zhangjiagang Hosp, Dept Burns & Plast Surg, Suzhou, Peoples R China

来源：

FUTURE MICROBIOLOGY | 2025年 / 20卷 / 06期

关键词：

Klebsiella pneumoniae; virulence factor; multidrug resistance; horizontal gene transfer; diagnostic microbiology; CARBAPENEM-RESISTANCE; MOLECULAR EPIDEMIOLOGY; BIOFILM FORMATION; VIRULENCE; AEROBACTIN; EMERGENCE; ENTEROBACTERALES; SALMOCHELIN; INFECTIONS; MECHANISMS;

D O I：

10.1080/17460913.2025.2482478

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-hvKP) combines high pathogenicity with multidrug resistance to become a new superbug. MDR-hvKP reports continue to emerge, shattering the perception that hypervirulent K. pneumoniae (hvKP) strains are antibiotic sensitive. Patients infected with MDR-hvKP strains have been reported in Asia, particularly China. Although hvKP can acquire drug resistance genes, MDR-hvKP seems to be more easily transformed from classical K. pneumoniae (cKP), which has a strong gene uptake ability. To better understand the biology of MDR-hvKP, this review discusses the virulence factors, resistance mechanisms, formation pathways, and identification of MDR-hvKP. Given their destructive and transmissible potential, continued surveillance of these organisms and enhanced control measures should be prioritized.

引用

页码：499 / 511

页数：13

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