Prognostic and Predictive Role of SPOP Mutations in Prostate Cancer: A Systematic Review and Meta-analysis

被引：5

作者：

Pedrani, Martino ^{[1
,2
]}

Salfi, Giuseppe ^{[1
,3
]}

Merler, Sara ^{[1
,3
,4
,5
,6
]}

Testi, Irene ^{[1
,7
]}

Cani, Massimiliano ^{[1
,8
]}

Turco, Fabio ^{[1
]}

Trevisi, Elena ^{[1
]}

Tortola, Luigi ^{[1
]}

Treglia, Giorgio ^{[6
,9
,10
]}

Tanna, Gian Luca Di ^{[11
]}

Vogl, Ursula ^{[1
]}

Gillessen, Silke ^{[1
,6
]}

Theurillat, Jean-Philippe ^{[3
,6
]}

Mestre, Ricardo Pereira ^{[1
,3
,6
,12
]}

机构：

[1] Ente Osped Cantonale EOC, Oncol Inst Southern Switzerland IOSI, Bellinzona, Switzerland

[2] Univ Milan, Dept Oncol & Hematooncol, Milan, Italy

[3] Inst Oncol Res IOR, Bellinzona, Switzerland

[4] Univ Verona, Dept Engn Innovat Med, Sect Innovat Biomed Oncol Area, Verona, Italy

[5] Verona Univ Hosp Trust, Verona, Italy

[6] Univ Svizzera italiana, Fac Biomed Sci, Lugano, Switzerland

[7] Univ Hosp Parma, Med Oncol Unit, Parma, Italy

[8] Univ Turin, S Luigi Gonzaga Hosp, Dept Oncol, Oncol Unit, Orbassano, Italy

[9] Ente Osped Cantonale EOC, Imaging Inst Southern Switzerland, Bellinzona, Switzerland

[10] Univ Lausanne, Fac Biol & Med, Lausanne, Switzerland

[11] Univ Appl Sci & Arts Southern Switzerland, Dept Business Econ Hlth & Social Care, Manno, Switzerland

[12] myDoctorAngel, Clin Res Unit, Bioggio, Switzerland

来源：

EUROPEAN UROLOGY ONCOLOGY | 2024年 / 7卷 / 06期

关键词：

Speckle-type POZ; Prostate cancer; Systematic review; Meta-analysis; Androgen deprivation treatment; Abiraterone; Docetaxel; Survival; Predictive; ANDROGEN RECEPTOR; OUTCOMES; METASTASIS; THERAPY; FOXA1; RISK; GENE; MEN;

D O I：

10.1016/j.euo.2024.04.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Context: Mutations in the speckle-type POZ (SPOP) gene are frequently identified in prostate cancer (PC); yet, prognostic implications for affected patients remain unclear. Limited consensus exists regarding tailored treatments for SPOP-mutant (SPOPmut) PC. Objective: To elucidate the prognostic and predictive significance of SPOP mutations across distinct PC stages and treatments. Evidence acquisition: A systematic literature search of PubMed, Embase, and Scopus was conducted up to January 29, 2024. The meta-analysis included studies comparing survival outcomes between SPOPmut and SPOP wild-type (SPOPwt) PC. Evidence synthesis: From 669 records, 26 studies (including five abstracts) were analyzed. A meta-analysis of metastasis-free survival in localized (hazard ratio [HR]: 0.72, 95% confidence interval [CI]: 0.59-0.88; p <0.01) and overall survival (OS) in metastatic PC (HR: 0.64,95% CI: 0.53-0.76; p <0.01) showed a favorable prognosis for patients with SPOPmut PC. In metastatic settings, SPOP mutations correlated with improved progression-free survival (PFS) and OS in patients undergoing androgen deprivation therapy +/- androgen receptor signaling inhibitor (HR: 0.51, 95% CI: 0.35-0.76, p < 0.01, and HR: 0.60, 95% CI:0.46-0.79, p <0.01, respectively). In metastatic castration- resistant PC, only abiraterone provided improved PFS and OS to patients with SPOP mutations compared with patients with SPOPwt, but data were limited. SPOP mutations did not correlate with improved PFS (p = 0.80) or OS (p = 0.27) for docetaxel. Conclusions: Patients with SPOPmut PC seem to exhibit superior oncological outcomes compared with patients with SPOPwt. Tailored risk stratification and treatment approaches should be explored in such patients. Patient summary: Speckle-type POZ (SPOP) mutations could be a favorable prognostic factor in patients with prostate cancer (PC) and may also predict better progression- free and overall survival than treatment with hormonal agents. Therefore, less intensified treatments omitting chemotherapy for patients with SPOP-mutant PC should be explored in clinical trials. (c) 2024 The Author(s). Published by Elsevier B.V. on behalf of European Association of Urology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：1199 / 1215

页数：17

共 62 条

[1] Genomic correlates of clinical outcome in advanced prostate cancer [J].

Abida, Wassim ;

Cyrta, Joanna ;

Heller, Glenn ;

Prandi, Davide ;

Armenia, Joshua ;

Coleman, Ilsa ;

Cieslik, Marcin ;

Benelli, Matteo ;

Robinson, Dan ;

Van Allen, Eliezer M. ;

Sboner, Andrea ;

Fedrizzi, Tarcisio ;

Mosquera, Juan Miguel ;

Robinson, Brian D. ;

De Sarkar, Navonil ;

Kunju, Lakshmi P. ;

Tomlins, Scott ;

Wu, Yi Mi ;

Rodrigues, Daniel Nava ;

Loda, Massimo ;

Gopalan, Anuradha ;

Reuter, Victor E. ;

Pritchard, Colin C. ;

Mateo, Joaquin ;

Bianchini, Diletta ;

Miranda, Susana ;

Carreira, Suzanne ;

Rescigno, Pasquale ;

Filipenko, Julie ;

Vinson, Jacob ;

Montgomery, Robert B. ;

Beltran, Himisha ;

Heath, Elisabeth I. ;

Scher, Howard I. ;

Kantoff, Philip W. ;

Taplin, Mary-Ellen ;

Schultz, Nikolaus ;

deBono, Johann S. ;

Demichelis, Francesca ;

Nelson, Peter S. ;

Rubin, Mark A. ;

Chinnaiyan, Arul M. ;

Sawyers, Charles L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (23) :11428-11436

[2] Guidelines for Reporting of Statistics for Clinical Research in Urology [J].

Assel, Melissa ;

Sjoberg, Daniel ;

Elders, Andrew ;

Wang, Xuemei ;

Huo, Dezheng ;

Botchway, Albert ;

Delfino, Kristin ;

Fan, Yunhua ;

Zhao, Zhiguo ;

Koyama, Tatsuki ;

Hollenbeck, Brent ;

Qin, Rui ;

Zahnd, Whitney ;

Zabor, Emily C. ;

Kattan, Michael W. ;

Vickers, Andrew J. .

JOURNAL OF UROLOGY, 2019, 201 (03) :595-604

[3] Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer [J].

Barbieri, Christopher E. ;

Baca, Sylvan C. ;

Lawrence, Michael S. ;

Demichelis, Francesca ;

Blattner, Mirjam ;

Theurillat, Jean-Philippe ;

White, Thomas A. ;

Stojanov, Petar ;

Van Allen, Eliezer ;

Stransky, Nicolas ;

Nickerson, Elizabeth ;

Chae, Sung-Suk ;

Boysen, Gunther ;

Auclair, Daniel ;

Onofrio, Robert C. ;

Park, Kyung ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Sheikh, Karen ;

Vuong, Terry ;

Guiducci, Candace ;

Cibulskis, Kristian ;

Sivachenko, Andrey ;

Carter, Scott L. ;

Saksena, Gordon ;

Voet, Douglas ;

Hussain, Wasay M. ;

Ramos, Alex H. ;

Winckler, Wendy ;

Redman, Michelle C. ;

Ardlie, Kristin ;

Tewari, Ashutosh K. ;

Mosquera, Juan Miguel ;

Rupp, Niels ;

Wild, Peter J. ;

Moch, Holger ;

Morrissey, Colm ;

Nelson, Peter S. ;

Kantoff, Philip W. ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Lander, Eric S. ;

Getz, Gad ;

Rubin, Mark A. ;

Garraway, Levi A. .

NATURE GENETICS, 2012, 44 (06) :685-U107

[4] SPOP-mutant prostate cancer: Translating fundamental biology into patient care [J].

Bernasocchi, Tiziano ;

Theurillat, Jean-Philippe P. .

CANCER LETTERS, 2022, 529 :11-18

[5] Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer [J].

Bernasocchi, Tiziano ;

El Tekle, Geniver ;

Bolis, Marco ;

Mutti, Azzurra ;

Vallerga, Arianna ;

Brandt, Laura P. ;

Spriano, Filippo ;

Svinkina, Tanya ;

Zoma, Marita ;

Ceserani, Valentina ;

Rinaldi, Anna ;

Janouskova, Hana ;

Bossi, Daniela ;

Cavalli, Manuela ;

Mosole, Simone ;

Geiger, Roger ;

Dong, Ze ;

Yang, Cai-Guang ;

Albino, Domenico ;

Rinaldi, Andrea ;

Schraml, Peter ;

Linder, Simon ;

Carbone, Giuseppina M. ;

Alimonti, Andrea ;

Bertoni, Francesco ;

Moch, Holger ;

Carr, Steven A. ;

Zwart, Wilbert ;

Kruithof-de Julio, Marianna ;

Rubin, Mark A. ;

Udeshi, Namrata D. ;

Theurillat, Jean-Philippe P. .

NATURE COMMUNICATIONS, 2021, 12 (01)

[6] SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling [J].

Blattner, Mirjam ;

Liu, Deli ;

Robinson, Brian D. ;

Huang, Dennis ;

Poliakov, Anton ;

Gao, Dong ;

Nataraj, Srilakshmi ;

Deonarine, Lesa D. ;

Augello, Michael A. ;

Sailer, Verena ;

Ponnala, Lalit ;

Ittmann, Michael ;

Chinnaiyan, Arul M. ;

Sboner, Andrea ;

Chen, Yu ;

Rubin, Mark A. ;

Barbieri, Christopher E. .

CANCER CELL, 2017, 31 (03) :436-451

[7] SPOP Mutations in Prostate Cancer across Demographically Diverse Patient Cohorts [J].

Blattner, Mirjam ;

Lee, Daniel J. ;

O'Reilly, Catherine ;

Park, Kyung ;

MacDonald, Theresa Y. ;

Khani, Francesca ;

Turner, Kevin R. ;

Chiu, Ya-Lin ;

Wild, Peter J. ;

Dolgalev, Igor ;

Heguy, Adriana ;

Sboner, Andrea ;

Ramazangolu, Sinan ;

Hieronymus, Haley ;

Sawyers, Charles ;

Tewari, Ashutosh K. ;

Moch, Holger ;

Yoon, Ghil Suk ;

Known, Yong Chul ;

Andren, Ove ;

Fall, Katja ;

Demichelis, Francecsa ;

Mosquera, Juan Miguel ;

Robinson, Brian D. ;

Barbieri, Christopher E. ;

Rubin, Mark A. .

NEOPLASIA, 2014, 16 (01) :14-U34

[8] SPOP-Mutated/CHD1-Deleted Lethal Prostate Cancer and Abiraterone Sensitivity [J].

Boysen, Gunther ;

Rodrigues, Daniel N. ;

Rescigno, Pasquale ;

Seed, George ;

Dolling, David ;

Riisnaes, Ruth ;

Crespo, Mateus ;

Zafeiriou, Zafeiris ;

Sumanasuriya, Semini ;

Bianchini, Diletta ;

Hunt, Joanne ;

Moloney, Deirdre ;

Perez-Lopez, Raquel ;

Tunariu, Nina ;

Miranda, Susana ;

Figueiredo, Ines ;

Ferreira, Ana ;

Christova, Rossitza ;

Gil, Veronica ;

Aziz, Sara ;

Bertan, Claudia ;

de Oliveira, Flavia M. ;

Atkin, Mark ;

Clarke, Matthew ;

Goodall, Jane ;

Sharp, Adam ;

MacDonald, Theresa ;

Rubin, Mark A. ;

Yuan, Wei ;

Barbieri, Christopher E. ;

Carreira, Suzanne ;

Mateo, Joaquin ;

de Bono, Johann S. .

CLINICAL CANCER RESEARCH, 2018, 24 (22) :5585-5593

[9] SPOP mutation leads to genomic instability in prostate cancer [J].

Boysen, Gunther ;

Barbieri, Christopher E. ;

Prandi, Davide ;

Blattner, Mirjam ;

Chae, Sung-Suk ;

Dahija, Arun ;

Nataraj, Srilakshmi ;

Huang, Dennis ;

Marotz, Clarisse ;

Xu, Limei ;

Huang, Julie ;

Lecca, Paola ;

Chhangawala, Sagar ;

Liu, Deli ;

Zhou, Pengbo ;

Sboner, Andrea ;

de Bono, Johann S. ;

Demichelis, Francesca ;

Houvras, Yariv ;

Rubin, Mark A. .

ELIFE, 2015, 4

[10] Opposing Roles of SPOP Mutations in Human Prostate and Endometrial Cancers [J].

Cavalcante, Ludimila ;

Deshmukh, Sachin Kumar ;

Ribeiro, Jennifer R. ;

Carneiro, Benedito A. ;

Dizon, Don S. ;

Angara, Kartik ;

Mattox, Tyler ;

Wu, Sharon ;

Xiu, Joanne ;

Walker, Phillip ;

Oberley, Matthew ;

Nabhan, Chadi ;

Huang, Haojie ;

Antonarakis, Emmanuel S. .

JCO PRECISION ONCOLOGY, 2023, 7

← 1 2 3 4 5 6 7 →