Current Applications and Future Directions for Vascular Stents with Stem Cells in the Treatment of Intracranial Aneurysms: A Mini-Review

被引：0

作者：

Chattopadhyay, Kaustav ^{[1
]}

Sreenivasan, Sanjeev ^{[2
]}

Gupta, Gaurav ^{[1
]}

Abramyan, Arevik ^{[1
]}

Filho, Idiberto Jose Zotarelli ^{[3
,4
]}

Sundararajan, Srihari ^{[5
]}

Nanda, Anil ^{[1
]}

Roychowdhury, Sudipta ^{[5
]}

机构：

[1] Rutgers Robert Wood Johnson Med Sch, Dept Neurosurg, Piscataway, NJ USA

[2] Northshore Univ Hosp, Dept Neurosurg, Northwell Hlth, New York, NY USA

[3] UNESP Sao Paulo State Univ, Inst Biosci Humanities & Exact Sci Ibilce, Postgrad Program Food Nutr & Food Engn, Campus Sao Jose do Rio Preto, Sao Jose Do Rio Preto, SP, Brazil

[4] Brazilian Assoc Nutrol, ABRAN Assoc Brasileira Nutrol, Catanduva, SP, Brazil

[5] Rutgers Robert Wood Johnson Med Sch, Univ Radiol, Dept Intervent Radiol, New Bruswick, NJ USA

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2025年

关键词：

Stem cells; vascular stents; endovascular; intracranial aneurysms; SMOOTH-MUSCLE-CELLS; MECHANISMS; GROWTH;

D O I：

10.2174/011574888X329158241015053444

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Vascular stents and stem cells have been used in high-acuity cases for many decades, particularly in cardiology. Providing the physician with another avenue of treatment, they have had a reasonable amount of success. However, there has been very little research conducted on seeding vascular stents with stem cells when treating intracranial aneurysms. Our work aims to understand the current literature available on the viability of such stents and the future directions one should take when choosing stents seeded with stem cells. Three computerized searches in PubMed were used. Four papers met the criteria, and two were excluded. There have been some experiments where the efficacy of vascular stents seeded with different materials was tested. G/PLL-coated stents provided multiple advantages and bioactive benefits to the mesenchymal stem cells. On the other hand, SF/SDF-1 alpha also promoted similar benefits but provoked multiple unwanted inflammatory responses. G/PLL and SF/SDF-1 alpha coated stents were able to provide satisfactory results but still require more extensive research to thoroughly understand their efficacies and safety. Future directions may include researching and discovering a wider array of biocompatible materials to seed the stents.

引用

页数：5