Stearic acid metabolism in human health and disease

被引：0
作者：
Shen, Xinyi [1 ,2 ]
Miao, Shuo [2 ]
Zhang, Yaping [3 ]
Guo, Xingying [3 ]
Li, Wenxian [1 ]
Mao, Xin [1 ]
Zhang, Qingsong [1 ]
机构：
[1] Qingdao Univ, Dept Urol, Affiliated Hosp, Qingdao, Peoples R China
[2] Qingdao Univ, Sch Basic Med, Qingdao, Peoples R China
[3] Qingdao Univ, Dept Operating Room, Affiliated Hosp, Qingdao, Peoples R China
来源：
CLINICAL NUTRITION | 2025年 / 44卷
基金：
美国国家科学基金会;
关键词：
Stearic acid; Metabolic syndrome; Cardiovascular diseases; Cancer; Neurodegenerative diseases; INFLUENZA-VIRUS HEMAGGLUTININ; CORONARY-HEART-DISEASE; SATURATED FATTY-ACIDS; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED RECEPTORS PPARS; SITE-SPECIFIC ATTACHMENT; BREAST-CANCER PATIENTS; WHITE ADIPOSE-TISSUE; OLEIC-ACID; CELL-DEATH;
D O I：
10.1016/j.clnu.2024.12.012
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Named after the Greek term for "hard fat", stearic acid has gradually entered people's field of vision. As an important component of various physiological cellular functions, stearic acid plays a regulatory role in diverse aspects of energy metabolism and signal transduction. Its applications range from serving as a bodily energy source to participating in endogenous biosynthesis. Similar to palmitate, stearic acid serves as a primary substrate for the stearoyl coenzyme A desaturase, which catalyzes the conversion of stearate to oleate and is involved in the synthesis of triglyceride and other complex lipids. Additionally, stearic acid functions as a vital signaling molecule in pathological processes such as cardiovascular diseases, diabetes development, liver injury and even nervous system disorders. Therefore, we conduct a comprehensive review of stearic acid, summarizing its role in various diseases and attempting to provide a systematic overview of its homeostasis, physiological functions, and pathological process. From a medical standpoint, we also explore potential applications and discuss stearic acid as a potential therapeutic target for the treatment of human diseases. (c) 2024 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
引用
收藏
页码：222 / 238
页数：17
相关论文
共 314 条
  • [11] Metabolic and anthropometric changes in early breast cancer patients receiving adjuvant therapy
    Arpino, Grazia
    De Angelis, Carmine
    Buono, Giuseppe
    Colao, Annamaria
    Giuliano, Mario
    Malgieri, Simona
    Cicala, Stefania
    De Laurentiis, Michelino
    Accurso, Antonello
    Crispo, Anna
    Limite, Gennaro
    Lauria, Rossella
    Veneziani, Bianca Maria
    Forestieri, Valeria
    Bruzzese, Dario
    De Placido, Sabino
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2015, 154 (01) : 127 - 132
  • [12] Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure
    Artwohl, Michaela
    Lindenmair, Andrea
    Roden, Michael
    Waldhaeusl, Werner-Klaus
    Freudenthalera, Angelika
    Klosner, Gabriele
    Ilhan, Ayseguel
    Luger, Anton
    Baumgartner-Parzer, Sabina M.
    [J]. ATHEROSCLEROSIS, 2009, 202 (02) : 351 - 362
  • [13] Fast removal of synaptic glutamate by postsynaptic transporters
    Auger, C
    Attwell, D
    [J]. NEURON, 2000, 28 (02) : 547 - 558
  • [14] Obesity and cancer risk: Emerging biological mechanisms and perspectives
    Avgerinos, Konstantinos, I
    Spyrou, Nikolaos
    Mantzoros, Christos S.
    Dalamaga, Maria
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 2019, 92 : 121 - 135
  • [15] Carcinogenesis alters fatty acid profile in breast tissue
    Azordegan, Nazila
    Fraser, Virginia
    Le, Khuong
    Hillyer, Lyn M.
    Ma, David W. L.
    Fischer, Gabor
    Moghadasian, Mohammed H.
    [J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2013, 374 (1-2) : 223 - 232
  • [16] Structural and barrier properties of the skin ceramide lipid bilayer: a molecular dynamics simulation study
    Badhe, Yogesh
    Gupta, Rakesh
    Rai, Beena
    [J]. JOURNAL OF MOLECULAR MODELING, 2019, 25 (05)
  • [17] Diet and Cardiovascular Disease: Effects of Foods and Nutrients in Classical and Emerging Cardiovascular Risk Factors
    Badimon, Lina
    Chagas, Patricia
    Chiva-Blanch, Gemma
    [J]. CURRENT MEDICINAL CHEMISTRY, 2019, 26 (19) : 3639 - 3651
  • [18] Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis
    Barreyro, Fernando J.
    Kobayashi, Shogo
    Bronk, Steven F.
    Werneburg, Nathan W.
    Malhi, Harmeet
    Gores, Gregory J.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (37) : 27141 - 27154
  • [19] BAUER KA, 1990, BLOOD, V76, P731
  • [20] Lipid signaling in neural plasticity, brain repair, and neuroprotection
    Bazan, NG
    [J]. MOLECULAR NEUROBIOLOGY, 2005, 32 (01) : 89 - 103
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