Differential Response of GCN2 eIF2 Kinase to Specific Amino Acid Limitations in Prostate Cancer

被引:0
|
作者
Brady, Katherine [1 ]
Cordova, Ricardo [1 ]
Sommers, Noah [1 ]
Wek, Ronald [1 ]
Staschke, Kirk [1 ]
机构
[1] IU Indianapolis, Indianapolis, IN USA
关键词
Prostate Cancer; GCN2; Amino acids; Integrated Stress Response; Starvation;
D O I
10.1016/j.jbc.2024.106457
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
1691
引用
收藏
页码:S384 / S385
页数:2
相关论文
共 50 条
  • [1] GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
    Cordova, Ricardo A.
    Misra, Jagannath
    Amin, Parth H.
    Klunk, Anglea J.
    Damayanti, Nur P.
    Carlson, Kenneth R.
    Elmendorf, Andrew J.
    Kim, Hyeong-Geug
    Mirek, Emily T.
    Elzey, Bennet D.
    Miller, Marcus J.
    Dong, X. Charlie
    Cheng, Liang
    Anthony, Tracy G.
    Pili, Robero
    Wek, Ronald C.
    Staschke, Kirk A.
    ELIFE, 2022, 11
  • [2] GCN2 eIF2 kinase and p53 coordinate amino acid homeostasis and metabolism in prostate cancer
    Cordova, Ricardo A.
    Sommers, Noah R.
    Klunk, Angela J.
    Mohiuddin, Haroon M.
    Pili, Roberto
    Wek, Ronald C.
    Staschke, Kirk A.
    CANCER RESEARCH, 2023, 83 (07)
  • [3] The GCN2 eIF2α kinase is required for adaptation to amino acid deprivation in mice
    Zhang, PC
    McGrath, BC
    Reinert, J
    Olsen, DS
    Lei, L
    Gill, S
    Wek, SA
    Vattem, KM
    Wek, RC
    Kimball, SR
    Jefferson, LS
    Cavener, DR
    MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (19) : 6681 - 6688
  • [4] The eIF2 kinase GCN2 controls expression of key amino acid transporters and is critical for prostate cancer growth and progression
    Cordova, Ricardo
    Misra, Jagannath
    Damayanti, Nur P.
    Amin, Parth H.
    Carlson, Kenneth R.
    Klunk, Angela J.
    Mirek, Emily T.
    Miller, Marcus J.
    Anthony, Tracy G.
    Pili, Roberto
    Wek, Ronald C.
    Staschke, Kirk A.
    CANCER RESEARCH, 2022, 82 (12)
  • [5] Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae
    Zaborske, John M.
    Wu, Xiaochen
    Wek, Ronald C.
    Pan, Tao
    BMC BIOCHEMISTRY, 2010, 11
  • [6] Keeping the eIF2 alpha kinase Gcn2 in check
    Castilho, Beatriz A.
    Shanmugam, Renuka
    Silva, Richard C.
    Ramesh, Rashmi
    Himme, Benjamin M.
    Sattlegger, Evelyn
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2014, 1843 (09): : 1948 - 1968
  • [7] The eIF2 Kinase GCN2 Is Essential for the Murine Immune System to Adapt to Amino Acid Deprivation by Asparaginase
    Bunpo, Piyawan
    Cundiff, Judy K.
    Reinert, Rachel B.
    Wek, Ronald C.
    Aldrich, Carla J.
    Anthony, Tracy G.
    JOURNAL OF NUTRITION, 2010, 140 (11): : 2020 - 2027
  • [8] The amino-acid stress sensing eIF2α kinase GCN2 is a survival biomarker for malignant mesothelioma
    Lyssa T. Gold
    Susan E. Bray
    Neil M. Kernohan
    Nina Henderson
    Maisie Nowicki
    Glenn R. Masson
    BJC Reports, 1 (1):
  • [9] The GCN2 eIF2α kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid
    Guo, Feifan
    Cavener, Douglas R.
    CELL METABOLISM, 2007, 5 (02) : 103 - 114
  • [10] Multiple mechanisms activate GCN2 eIF2 kinase in response to diverse stress conditions
    Misra, Jagannath
    Carlson, Kenneth R.
    Spandau, Dan F.
    Wek, Ronald C.
    NUCLEIC ACIDS RESEARCH, 2024, 52 (04) : 1830 - 1846