Development of anti-cancer drugs for tumor-associated macrophages: a comprehensive review and mechanistic insights

被引:1
作者
Bai, Bingjun [1 ]
Xie, Shangzhi [2 ]
Wang, Ya [3 ]
Wu, Fei [4 ]
Chen, Yao [5 ]
Bian, Jia [6 ]
Gao, Xing [7 ]
机构
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Colorectal Surg, Hangzhou, Peoples R China
[2] Wenzhou Med Univ, Inst Genom Med, Wenzhou, Peoples R China
[3] Zhejiang Canc Hosp, Dept Hosp Infect Control, Hangzhou, Peoples R China
[4] Zhejiang Univ, Inst Syst Med, Sch Med, Hangzhou, Peoples R China
[5] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Med Oncol, Hangzhou, Peoples R China
[6] Ningbo Univ, Affiliated Peoples Hosp, Dept Gynecol & Obstet, Ningbo, Zhejiang, Peoples R China
[7] Soochow Univ, Affiliated Hosp 2, Dept Oncol, Suzhou, Jiangsu, Peoples R China
关键词
tumor-associated macrophages (TAMs); tumor microenvironment (TME); TAMs-targeted therapies; macrophage polarization; M1 and M2 macrophages; LUNG-CANCER; HOMEOSTASIS; INHIBITION; ROLES; TAMS;
D O I
10.3389/fmolb.2024.1463061
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review provides an in-depth summary of the development of anti-cancer drugs for tumor-associated macrophages (TAMs), with a particular focus on the development and tissue specialization of macrophages, and factors influencing the polarization of M1 and M2 macrophages, and mechanistic insights underlying the targeting therapeutic approaches. TAMs, pivotal in the tumor microenvironment, exhibit notable plasticity and diverse functional roles. Influenced by the complex milieu, TAMs polarize into M1-type, which suppresses tumors, and M2-type, which promotes metastasis. Notably, targeting M2-TAMs is a promising strategy for tumor therapy. By emphasizing the importance of macrophages as a therapeutic target of anti-cancer drugs, this review aims to provide valuable insights and research directions for clinicians and researchers.
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页数:9
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共 63 条
  • [1] Biology of lung macrophages in health and disease
    Aegerter, Helena
    Lambrecht, Bart N.
    Jakubzick, Claudia, V
    [J]. IMMUNITY, 2022, 55 (09) : 1564 - 1580
  • [2] Anderson NM, 2020, CURR BIOL, V30, pR921, DOI 10.1016/j.cub.2020.06.081
  • [3] Current Strategies to Target Tumor-Associated-Macrophages to Improve Anti-Tumor Immune Responses
    Anfray, Clement
    Ummarino, Aldo
    Torres Andon, Fernando
    Allavena, Paola
    [J]. CELLS, 2020, 9 (01)
  • [4] Phase I Study of the CD47 Blocker TTI-621 in Patients with Relapsed or Refractory Hematologic Malignancies
    Ansell, Stephen M.
    Maris, Michael B.
    Lesokhin, Alexander M.
    Chen, Robert W.
    Flinn, Ian W.
    Sawas, Ahmed
    Minden, Mark D.
    Villa, Diego
    Percival, Mary-Elizabeth M.
    Advani, Anjali S.
    Foran, James M.
    Horwitz, Steven M.
    Mei, Matthew G.
    Zain, Jasmine
    Savage, Kerry J.
    Querfeld, Christiane
    Akilov, Oleg E.
    Johnson, Lisa D. S.
    Catalano, Tina
    Petrova, Penka S.
    Uger, Robert A.
    Sievers, Eric L.
    Milea, Anca
    Roberge, Kathleen
    Shou, Yaping
    O'Connor, Owen A.
    [J]. CLINICAL CANCER RESEARCH, 2021, 27 (08) : 2190 - 2199
  • [5] Roles of macrophages in tumor development: a spatiotemporal perspective
    Bied, Mathilde
    Ho, William W.
    Ginhoux, Florent
    Bleriot, Camille
    [J]. CELLULAR & MOLECULAR IMMUNOLOGY, 2023, 20 (09) : 983 - 992
  • [6] The Promise of Targeting Macrophages in Cancer Therapy
    Brown, J. Martin
    Recht, Lawrence
    Strober, Samuel
    [J]. CLINICAL CANCER RESEARCH, 2017, 23 (13) : 3241 - 3250
  • [7] Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21
    Caescu, Cristina I.
    Guo, Xingyi
    Tesfa, Lydia
    Bhagat, Tushar D.
    Verma, Amit
    Zheng, Deyou
    Stanley, E. Richard
    [J]. BLOOD, 2015, 125 (08) : E1 - E13
  • [8] The Role of Tumor Associated Macrophages (TAMs) in Cancer Pro-gression, Chemoresistance, Angiogenesis and Metastasis-Current Status
    Dallavalasa, Siva
    Beeraka, Narasimha M.
    Basavaraju, Chaithanya G.
    Tulimilli, SubbaRao, V
    Sadhu, Surya Prabha
    Rajesh, Konathala
    Aliev, Gjumrakch
    Madhunapantula, SubbaRao, V
    [J]. CURRENT MEDICINAL CHEMISTRY, 2021, 28 (39) : 8203 - 8236
  • [9] CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy
    Escamilla, Jemima
    Schokrpur, Shiruyeh
    Liu, Connie
    Priceman, Saul J.
    Moughon, Diana
    Jiang, Ziyue
    Pouliot, Frederic
    Magyar, Clara
    Sung, James L.
    Xu, Jingying
    Deng, Gang
    West, Brian L.
    Bollag, Gideon
    Fradet, Yves
    Lacombe, Louis
    Jung, Michael E.
    Huang, Jiaoti
    Wu, Lily
    [J]. CANCER RESEARCH, 2015, 75 (06) : 950 - 962
  • [10] Phagocytosis checkpoints as new targets for cancer immunotherapy
    Feng, Mingye
    Jiang, Wen
    Kim, Betty Y. S.
    Zhang, Cheng Cheng
    Fu, Yang-Xin
    Weissman, Irving L.
    [J]. NATURE REVIEWS CANCER, 2019, 19 (10) : 568 - 586