Curcumin (CUR) is a polyphenol known for its therapeutic potential, but faces limitations in clinical application due to its poor aqueous solubility and low bioavailability. This study envisaged developing stable ternary inclusion complexes of CUR with beta-cyclodextrin (beta CD) and ascorbic acid (AA) as the ternary substance. Inclusion complexes were prepared by kneading and autoclaving method. Phase solubility studies revealed that the A(L) type relation between CUR and beta CD. We observed The AA improved the stability of the ternary complexes with its stability constant as 138.8M(- 1), complexation efficiency as 0.198, utility number as 3.96 and the bulk as 4.80. The solubilization power improved from - 17.42 to 1.33. Cytotoxicity assays using the A549 lung cancer cell line demonstrated that the ternary complex exhibits potent anticancer activity, comparable to pure CUR. In vitro dissolution tests showed a marked increase in the release rate of CUR from the ternary complex. Our study demonstrates that the inclusion of AA significantly enhances the solubility, stability, and biological efficacy of CUR. The higher stability constant and complexation efficiency of CUR-beta CD-AA was due to improved interaction facilitated by AA. The inclusion complexes showed improved antibacterial activity against Staphylococcus aureas and Staphylococcus epidermis Enhanced dissolution rates and strong cytotoxic effects against A549 lung cancer cells further support the potential of this ternary complex in overcoming CUR's bioavailability limitations. These results suggest that the CUR-beta CD-AA ternary complex effectively enhances curcumin's solubility, stability, and anticancer activity, offering a promising formulation strategy to overcome curcumin's bioavailability challenges and improve its therapeutic potential.
机构:
Ton Duc Thang Univ, Lab Theoret & Computat Biophys, Ho Chi Minh City, Vietnam
Ton Duc Thang Univ, Fac Appl Sci, Ho Chi Minh City, VietnamTon Duc Thang Univ, Lab Theoret & Computat Biophys, Ho Chi Minh City, Vietnam
Adeyemi, Oluyomi Stephen
Obeme-Imom, Joy Ihuoma
论文数: 0引用数: 0
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机构:
Landmark Univ, Dept Biochem, Med Biochem Nanomed & Toxicol Lab, PMB 1001, Omu Aran 251101, NigeriaTon Duc Thang Univ, Lab Theoret & Computat Biophys, Ho Chi Minh City, Vietnam
Obeme-Imom, Joy Ihuoma
Akpor, Benjamin Oghenerobor
论文数: 0引用数: 0
h-index: 0
机构:
Landmark Univ, Dept Microbiol, PMB 1001, Omu Aran 251101, NigeriaTon Duc Thang Univ, Lab Theoret & Computat Biophys, Ho Chi Minh City, Vietnam
Akpor, Benjamin Oghenerobor
Rotimi, Damilare
论文数: 0引用数: 0
h-index: 0
机构:
Landmark Univ, Dept Biochem, Med Biochem Nanomed & Toxicol Lab, PMB 1001, Omu Aran 251101, NigeriaTon Duc Thang Univ, Lab Theoret & Computat Biophys, Ho Chi Minh City, Vietnam
Rotimi, Damilare
Batiha, Gaber El-Saber
论文数: 0引用数: 0
h-index: 0
机构:
Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Abadiyyat Damanhur, EgyptTon Duc Thang Univ, Lab Theoret & Computat Biophys, Ho Chi Minh City, Vietnam
Batiha, Gaber El-Saber
Owolabi, Akinyomade
论文数: 0引用数: 0
h-index: 0
机构:
Landmark Univ, Dept Microbiol, PMB 1001, Omu Aran 251101, NigeriaTon Duc Thang Univ, Lab Theoret & Computat Biophys, Ho Chi Minh City, Vietnam
机构:
King Saud Univ, Dept Pharmaceut, Coll Pharm, Riyadh 11451, Saudi Arabia
Almareefa Univ, Coll Pharm, Riyadh 13713, Saudi ArabiaKing Saud Univ, Dept Pharmaceut, Coll Pharm, Riyadh 11451, Saudi Arabia
Alshehri, Sultan
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机构:
Imam, Syed Sarim
Hussain, Afzal
论文数: 0引用数: 0
h-index: 0
机构:
King Saud Univ, Dept Pharmaceut, Coll Pharm, Riyadh 11451, Saudi ArabiaKing Saud Univ, Dept Pharmaceut, Coll Pharm, Riyadh 11451, Saudi Arabia
Hussain, Afzal
Altamimi, Mohammad A.
论文数: 0引用数: 0
h-index: 0
机构:
King Saud Univ, Dept Pharmaceut, Coll Pharm, Riyadh 11451, Saudi ArabiaKing Saud Univ, Dept Pharmaceut, Coll Pharm, Riyadh 11451, Saudi Arabia
机构:
Prince Sattam Abdul Aziz Univ, Coll Pharm, Dept Pharmaceut, Al Kharj, Saudi Arabia
Jamia Hamdard, Dept Pharmaceut, Sch Pharmaceut Educ & Res, New Delhi, IndiaPrince Sattam Abdul Aziz Univ, Coll Pharm, Dept Pharmaceut, Al Kharj, Saudi Arabia
Ansari, M. J.
Kohli, K.
论文数: 0引用数: 0
h-index: 0
机构:
Jamia Hamdard, Dept Pharmaceut, Sch Pharmaceut Educ & Res, New Delhi, IndiaPrince Sattam Abdul Aziz Univ, Coll Pharm, Dept Pharmaceut, Al Kharj, Saudi Arabia
Kohli, K.
Ali, J.
论文数: 0引用数: 0
h-index: 0
机构:
Jamia Hamdard, Dept Pharmaceut, Sch Pharmaceut Educ & Res, New Delhi, IndiaPrince Sattam Abdul Aziz Univ, Coll Pharm, Dept Pharmaceut, Al Kharj, Saudi Arabia
机构:
Fed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, BrazilFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
Barbosa, Jahamunna A. A.
Zoppi, Ariana
论文数: 0引用数: 0
h-index: 0
机构:
UNC, CONICET, UNITEFA, Res & Pharmaceut Technol Dev Unit, Cordoba, Argentina
Natl Univ Cordoba, Fac Chem Sci, Dept Pharm, Cordoba, ArgentinaFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
Zoppi, Ariana
Quevedo, Mario A.
论文数: 0引用数: 0
h-index: 0
机构:
UNC, CONICET, UNITEFA, Res & Pharmaceut Technol Dev Unit, Cordoba, Argentina
Natl Univ Cordoba, Fac Chem Sci, Dept Pharm, Cordoba, ArgentinaFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
Quevedo, Mario A.
de Melo, Polyanne N.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Norte, Grad Program Dev & Technol Innovat Pharmaceut, BR-59072970 Natal, RN, BrazilFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
de Melo, Polyanne N.
de Medeiros, Arthur S. A.
论文数: 0引用数: 0
h-index: 0
机构:
Fed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, BrazilFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
de Medeiros, Arthur S. A.
Streck, Leticia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Norte, Grad Program Dev & Technol Innovat Pharmaceut, BR-59072970 Natal, RN, BrazilFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
Streck, Leticia
de Oliveira, Alice R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Norte, Grad Program Hlth Sci, BR-59072570 Natal, RN, BrazilFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
de Oliveira, Alice R.
Fernandes-Pedrosa, Matheus F.
论文数: 0引用数: 0
h-index: 0
机构:
Fed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, BrazilFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
Fernandes-Pedrosa, Matheus F.
Longhi, Marcela R.
论文数: 0引用数: 0
h-index: 0
机构:
UNC, CONICET, UNITEFA, Res & Pharmaceut Technol Dev Unit, Cordoba, Argentina
Natl Univ Cordoba, Fac Chem Sci, Dept Pharm, Cordoba, ArgentinaFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
Longhi, Marcela R.
da Silva-Junior, Arnobio A.
论文数: 0引用数: 0
h-index: 0
机构:
Fed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
Univ Fed Rio Grande do Norte, Grad Program Dev & Technol Innovat Pharmaceut, BR-59072970 Natal, RN, Brazil
Univ Fed Rio Grande do Norte, Grad Program Hlth Sci, BR-59072570 Natal, RN, BrazilFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
da Silva-Junior, Arnobio A.
[J].
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,
2014,
15
(09):
: 17077
-
17099
机构:
Ton Duc Thang Univ, Lab Theoret & Computat Biophys, Ho Chi Minh City, Vietnam
Ton Duc Thang Univ, Fac Appl Sci, Ho Chi Minh City, VietnamTon Duc Thang Univ, Lab Theoret & Computat Biophys, Ho Chi Minh City, Vietnam
Adeyemi, Oluyomi Stephen
Obeme-Imom, Joy Ihuoma
论文数: 0引用数: 0
h-index: 0
机构:
Landmark Univ, Dept Biochem, Med Biochem Nanomed & Toxicol Lab, PMB 1001, Omu Aran 251101, NigeriaTon Duc Thang Univ, Lab Theoret & Computat Biophys, Ho Chi Minh City, Vietnam
Obeme-Imom, Joy Ihuoma
Akpor, Benjamin Oghenerobor
论文数: 0引用数: 0
h-index: 0
机构:
Landmark Univ, Dept Microbiol, PMB 1001, Omu Aran 251101, NigeriaTon Duc Thang Univ, Lab Theoret & Computat Biophys, Ho Chi Minh City, Vietnam
Akpor, Benjamin Oghenerobor
Rotimi, Damilare
论文数: 0引用数: 0
h-index: 0
机构:
Landmark Univ, Dept Biochem, Med Biochem Nanomed & Toxicol Lab, PMB 1001, Omu Aran 251101, NigeriaTon Duc Thang Univ, Lab Theoret & Computat Biophys, Ho Chi Minh City, Vietnam
Rotimi, Damilare
Batiha, Gaber El-Saber
论文数: 0引用数: 0
h-index: 0
机构:
Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Abadiyyat Damanhur, EgyptTon Duc Thang Univ, Lab Theoret & Computat Biophys, Ho Chi Minh City, Vietnam
Batiha, Gaber El-Saber
Owolabi, Akinyomade
论文数: 0引用数: 0
h-index: 0
机构:
Landmark Univ, Dept Microbiol, PMB 1001, Omu Aran 251101, NigeriaTon Duc Thang Univ, Lab Theoret & Computat Biophys, Ho Chi Minh City, Vietnam
机构:
King Saud Univ, Dept Pharmaceut, Coll Pharm, Riyadh 11451, Saudi Arabia
Almareefa Univ, Coll Pharm, Riyadh 13713, Saudi ArabiaKing Saud Univ, Dept Pharmaceut, Coll Pharm, Riyadh 11451, Saudi Arabia
Alshehri, Sultan
论文数: 引用数:
h-index:
机构:
Imam, Syed Sarim
Hussain, Afzal
论文数: 0引用数: 0
h-index: 0
机构:
King Saud Univ, Dept Pharmaceut, Coll Pharm, Riyadh 11451, Saudi ArabiaKing Saud Univ, Dept Pharmaceut, Coll Pharm, Riyadh 11451, Saudi Arabia
Hussain, Afzal
Altamimi, Mohammad A.
论文数: 0引用数: 0
h-index: 0
机构:
King Saud Univ, Dept Pharmaceut, Coll Pharm, Riyadh 11451, Saudi ArabiaKing Saud Univ, Dept Pharmaceut, Coll Pharm, Riyadh 11451, Saudi Arabia
机构:
Prince Sattam Abdul Aziz Univ, Coll Pharm, Dept Pharmaceut, Al Kharj, Saudi Arabia
Jamia Hamdard, Dept Pharmaceut, Sch Pharmaceut Educ & Res, New Delhi, IndiaPrince Sattam Abdul Aziz Univ, Coll Pharm, Dept Pharmaceut, Al Kharj, Saudi Arabia
Ansari, M. J.
Kohli, K.
论文数: 0引用数: 0
h-index: 0
机构:
Jamia Hamdard, Dept Pharmaceut, Sch Pharmaceut Educ & Res, New Delhi, IndiaPrince Sattam Abdul Aziz Univ, Coll Pharm, Dept Pharmaceut, Al Kharj, Saudi Arabia
Kohli, K.
Ali, J.
论文数: 0引用数: 0
h-index: 0
机构:
Jamia Hamdard, Dept Pharmaceut, Sch Pharmaceut Educ & Res, New Delhi, IndiaPrince Sattam Abdul Aziz Univ, Coll Pharm, Dept Pharmaceut, Al Kharj, Saudi Arabia
机构:
Fed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, BrazilFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
Barbosa, Jahamunna A. A.
Zoppi, Ariana
论文数: 0引用数: 0
h-index: 0
机构:
UNC, CONICET, UNITEFA, Res & Pharmaceut Technol Dev Unit, Cordoba, Argentina
Natl Univ Cordoba, Fac Chem Sci, Dept Pharm, Cordoba, ArgentinaFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
Zoppi, Ariana
Quevedo, Mario A.
论文数: 0引用数: 0
h-index: 0
机构:
UNC, CONICET, UNITEFA, Res & Pharmaceut Technol Dev Unit, Cordoba, Argentina
Natl Univ Cordoba, Fac Chem Sci, Dept Pharm, Cordoba, ArgentinaFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
Quevedo, Mario A.
de Melo, Polyanne N.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Norte, Grad Program Dev & Technol Innovat Pharmaceut, BR-59072970 Natal, RN, BrazilFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
de Melo, Polyanne N.
de Medeiros, Arthur S. A.
论文数: 0引用数: 0
h-index: 0
机构:
Fed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, BrazilFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
de Medeiros, Arthur S. A.
Streck, Leticia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Norte, Grad Program Dev & Technol Innovat Pharmaceut, BR-59072970 Natal, RN, BrazilFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
Streck, Leticia
de Oliveira, Alice R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Norte, Grad Program Hlth Sci, BR-59072570 Natal, RN, BrazilFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
de Oliveira, Alice R.
Fernandes-Pedrosa, Matheus F.
论文数: 0引用数: 0
h-index: 0
机构:
Fed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, BrazilFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
Fernandes-Pedrosa, Matheus F.
Longhi, Marcela R.
论文数: 0引用数: 0
h-index: 0
机构:
UNC, CONICET, UNITEFA, Res & Pharmaceut Technol Dev Unit, Cordoba, Argentina
Natl Univ Cordoba, Fac Chem Sci, Dept Pharm, Cordoba, ArgentinaFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
Longhi, Marcela R.
da Silva-Junior, Arnobio A.
论文数: 0引用数: 0
h-index: 0
机构:
Fed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
Univ Fed Rio Grande do Norte, Grad Program Dev & Technol Innovat Pharmaceut, BR-59072970 Natal, RN, Brazil
Univ Fed Rio Grande do Norte, Grad Program Hlth Sci, BR-59072570 Natal, RN, BrazilFed Univ Rio Grande Norte UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
da Silva-Junior, Arnobio A.
[J].
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,
2014,
15
(09):
: 17077
-
17099