A stable curcumin/β-cyclodextrin/ascorbic acid ternary inclusion complexes, docking studies, antimicrobial and anticancer assays

被引:0
作者
Ali, Md Sajid [1 ]
Shahrom, Nur Sarah binti Zainal [2 ]
Rajanderan, Thevashree [3 ]
Salawi, Ahmad [1 ]
Sabei, Fahad Y. [1 ]
Albariqi, Ahmed H. [1 ]
Sultan, Muhammad Hadi [1 ]
Alam, Mohammad Intakhab [1 ]
Alshamrani, Ayed A. [4 ]
Kumar, Arun [5 ]
Zhou, Lee Rhi [3 ]
Majeed, Shahnaz [2 ]
Ansari, Mohammed Tahir [3 ]
机构
[1] Jazan Univ, Coll Pharm, Dept Pharmaceut, Jazan 45142, Saudi Arabia
[2] Univ Kuala Lumpur, Dept Pharm, Royal Coll Med Perak, Ipoh 30450, Perak, Malaysia
[3] Univ Nottingham Malaysia, Fac Pharm & Hlth Sci, Sch Pharm, Jalan Broga, Semenyih 43500, Selangor, Malaysia
[4] Jazan Univ, Coll Pharm, Dept Pharmacol, Jazan 45142, Saudi Arabia
[5] Gurugram Univ, Dept Pharmaceut Sci & Brain Res, Gurugram 122003, Haryana, India
关键词
Curcumin; ascorbic acid; Beta cyclodextrin; A549; cells; Antimicrobial activity; IN-VITRO; STABILITY; SYSTEM; PROLIFERATION; NANOPARTICLES; TEMPERATURE; DISSOLUTION; MECHANISMS; EFFICIENCY; DELIVERY;
D O I
10.1007/s10847-025-01290-4
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Curcumin (CUR) is a polyphenol known for its therapeutic potential, but faces limitations in clinical application due to its poor aqueous solubility and low bioavailability. This study envisaged developing stable ternary inclusion complexes of CUR with beta-cyclodextrin (beta CD) and ascorbic acid (AA) as the ternary substance. Inclusion complexes were prepared by kneading and autoclaving method. Phase solubility studies revealed that the A(L) type relation between CUR and beta CD. We observed The AA improved the stability of the ternary complexes with its stability constant as 138.8M(- 1), complexation efficiency as 0.198, utility number as 3.96 and the bulk as 4.80. The solubilization power improved from - 17.42 to 1.33. Cytotoxicity assays using the A549 lung cancer cell line demonstrated that the ternary complex exhibits potent anticancer activity, comparable to pure CUR. In vitro dissolution tests showed a marked increase in the release rate of CUR from the ternary complex. Our study demonstrates that the inclusion of AA significantly enhances the solubility, stability, and biological efficacy of CUR. The higher stability constant and complexation efficiency of CUR-beta CD-AA was due to improved interaction facilitated by AA. The inclusion complexes showed improved antibacterial activity against Staphylococcus aureas and Staphylococcus epidermis Enhanced dissolution rates and strong cytotoxic effects against A549 lung cancer cells further support the potential of this ternary complex in overcoming CUR's bioavailability limitations. These results suggest that the CUR-beta CD-AA ternary complex effectively enhances curcumin's solubility, stability, and anticancer activity, offering a promising formulation strategy to overcome curcumin's bioavailability challenges and improve its therapeutic potential.
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页数:14
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