The Impact of Klotho in Cancer: From Development and Progression to Therapeutic Potential

被引：3

作者：

Ortega, Miguel A. ^{[1
,2
]}

Boaru, Diego Liviu ^{[1
,2
]}

De Leon-Oliva, Diego ^{[1
,2
]}

De Castro-Martinez, Patricia ^{[1
,2
]}

Minaya-Bravo, Ana M. ^{[1
,2
]}

Casanova-Martin, Carlos ^{[1
,2
]}

Barrena-Blazquez, Silvestra ^{[1
,2
,3
]}

Garcia-Montero, Cielo ^{[1
,2
]}

Fraile-Martinez, Oscar ^{[1
,2
]}

Lopez-Gonzalez, Laura ^{[2
,4
]}

Saez, Miguel A. ^{[1
,2
,5
]}

Alvarez-Mon, Melchor ^{[1
,2
,6
]}

Diaz-Pedrero, Raul ^{[2
,3
,4
]}

机构：

[1] Univ Alcala, Fac Med & Hlth Sci, Network Biomed Res Ctr Liver & Digest Dis CIBEREHD, Dept Med & Med Specialities, Alcala De Henares 28801, Spain

[2] Ramon y Cajal Inst Sanit Res IRYCIS, Madrid 28034, Spain

[3] Univ Hosp, Dept Gen & Digest Surg, Alcala De Henares 28805, Spain

[4] Univ Alcala, Fac Med & Hlth Sci, Dept Surg Med & Social Sci, Alcala De Henares 28801, Spain

[5] Cent Univ Hosp Def UAH Madrid, Pathol Anat Serv, Alcala De Henares 28801, Spain

[6] Univ Hosp Principe Asturias, Oncol Serv Internal Med CIBEREHD, Immune Syst Dis Rheumatol, Alcala De Henares 28806, Spain

来源：

GENES | 2025年 / 16卷 / 02期

关键词：

alpha-Klotho; beta-Klotho; gamma-Klotho; cancer; breast cancer; colorectal cancer; ALPHA-KLOTHO; TUMOR-SUPPRESSOR; OXIDATIVE STRESS; POOR-PROGNOSIS; OVARIAN-CANCER; GAMMA-KLOTHO; GROWTH; EXPRESSION; IDENTIFICATION; RESISTANCE;

D O I：

10.3390/genes16020128

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Klotho, initially identified as an anti-aging gene, has been shown to play significant roles in cancer biology. Alongside alpha-Klotho, the beta-Klotho and gamma-Klotho isoforms have also been studied; these studies showed that Klotho functions as a potential tumor suppressor in many different cancers by inhibiting cancer cell proliferation, inducing apoptosis and modulating critical signaling pathways such as the Wnt/beta-catenin and PI3K/Akt pathways. In cancers such as breast cancer, colorectal cancer, hepatocellular carcinoma, ovarian cancer, and renal cell carcinoma, reduced Klotho expression often correlates with a poor prognosis. In addition, Klotho's role in enhancing chemotherapy sensitivity and its epigenetic regulation further underscores its potential as a target for cancer treatments. This review details Klotho's multifaceted contributions to cancer suppression and its potential as a therapeutic target, enhancing the understanding of its significance in cancer treatment and prognoses.

引用

页数：23

共 146 条

[1] Biological and pharmacological functions of the FGF19-and FGF21-coreceptor beta klotho [J].