Host-targeted antivirals against SARS-CoV-2 in clinical development- Prospect or disappointment?

被引：2

作者：

Schreiber, Andre ^{[1
]}

Ludwig, Stephan ^{[1
]}

机构：

[1] Univ Munster, Inst Virol Muenster, Munster, Germany

来源：

ANTIVIRAL RESEARCH | 2025年 / 235卷

关键词：

Host-targeted antivirals; SARS-CoV-2; COVID-19; Therapeutic strategies; Virus-host interaction; Drug repurposing; BROAD-SPECTRUM; CYCLOSPORINE-A; VIRUS ACTIVITY; IN-VITRO; INHIBITOR; COVID-19; SAFETY; REPLICATION; BREQUINAR; EFFICACY;

D O I：

10.1016/j.antiviral.2025.106101

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The global response to the COVID-19 pandemic, caused by the novel SARS-CoV-2 virus, has seen an unprecedented increase in the development of antiviral therapies. Traditional antiviral strategies have primarily focused on direct-acting antivirals (DAAs), which specifically target viral components. In recent years, increasing attention was given to an alternative approach aiming to exploit host cellular pathways or immune responses to inhibit viral replication, which has led to development of so-called host-targeted antivirals (HTAs). The emergence of SARS-CoV-2 and COVID-19 has promoted a boost in this field. Numerous HTAs have been tested and demonstrated their potential against SARS-CoV-2 through in vitro and in vivo studies. However, in striking contrast, only a limited number have successfully progressed to advanced clinical trial phases (2-4), and even less have entered clinical practice. This review aims to explore the current landscape of HTAs targeting SARSCoV-2 that have reached phase 2-4 clinical trials. Additionally, it will explore the challenges faced in the development of HTAs and in gaining regulatory approval and market availability.

引用

页数：15

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