Low frequency deep brain stimulation of nucleus accumbens shell neuronal subpopulations attenuates cocaine seeking selectively in male rats

被引：0

作者：

Swinford-Jackson, Sarah E. ^{[1
,2
,3
]}

Rich, Matthew T. ^{[1
,2
,3
]}

Huffman, Phillip J. ^{[3
]}

Knouse, Melissa C. ^{[3
,4
,5
]}

Thomas, Arthur S. ^{[3
]}

Mankame, Sharvari ^{[1
,2
,6
]}

Worobey, Samantha J. ^{[1
,2
]}

Pierce, R. Christopher ^{[1
,2
,3
]}

机构：

[1] Rutgers Robert Wood Johnson Med Sch, Brain Hlth Inst, Piscataway, NJ 08854 USA

[2] Rutgers Robert Wood Johnson Med Sch, Dept Psychiat, Piscataway, NJ 08854 USA

[3] Univ Penn, Ctr Neurobiol & Behav, Perelman Sch Med, Philadelphia, PA 19104 USA

[4] Temple Univ, Dept Psychol, Philadelphia, PA 19122 USA

[5] Temple Univ, Neurosci Program, Philadelphia, PA 19122 USA

[6] Arizona State Univ, Dept Mol & Cellular Biol, Tempe, AZ 85287 USA

来源：

ADDICTION NEUROSCIENCE | 2023年 / 9卷

基金：

美国国家卫生研究院;

关键词：

Deep brain stimulation; Nucleus accumbens; Cocaine relapse; Optogenetics; LTP; ELECTRICAL-STIMULATION; INDUCED REINSTATEMENT; GLOBUS-PALLIDUS; SEX-DIFFERENCES; STN-DBS; PLASTICITY; MECHANISMS; MODULATION; ACTIVATION; WITHDRAWAL;

D O I：

10.1016/j.addicn.2023.100133

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study examined the effect of deep brain stimulation (DBS) in the nucleus accumbens shell on cocaine seeking and neuronal plasticity in rats. Electrical DBS of the accumbens shell attenuated cocaine primed reinstatement across a range of frequencies as low as 12 Hz in male rats. Nucleus accumbens medium spiny neurons (MSNs) can be differentiated by expression of dopamine D1 receptors (D1DRs) or D2DRs. Low-frequency optogenetic-DBS in D1DR- or D2DR-containing neurons attenuated cocaine seeking in male but not female rats. In slice electrophysiology experiments, 12 Hz electrical stimulation evoked long term potentiation (LTP) in D1DR-MSNs and D2DR-MSNs from cocaine naive male and female rats. However, in cocaine-experienced rats, electrical and optical DBS only elicited LTP in D2DR-MSNs from male rats. These results suggest that low frequency DBS in the nucleus accumbens shell effectively, but sex-specifically, suppresses cocaine seeking, which may be associated with the reversal of synaptic plasticity deficits in D2DR-MSNs.

引用

页数：12

共 50 条

[41] The effects of ceftriaxone on cue-primed reinstatement of cocaine-seeking in male and female rats: estrous cycle effects on behavior and protein expression in the nucleus accumbens [J].

Bechard, Allison R. ;

Hamor, Peter U. ;

Schwendt, Marek ;

Knackstedt, Lori A. .

PSYCHOPHARMACOLOGY, 2018, 235 (03) :837-848

[42] High-frequency electrical stimulation in the nucleus accumbens of morphine-treated rats suppresses neuronal firing in reward-related brain regions [J].

Hu, Wen-han ;

Bi, Yong-feng ;

Zhang, Kai ;

Meng, Fan-gang ;

Zhang, Jian-guo .

MEDICAL SCIENCE MONITOR, 2011, 17 (06) :BR153-BR160

[43] Antidepressant Action of Nucleus Accumbens High-Frequency Deep Brain Stimulation in Animal Model of Treatment Resistance [J].

Kale, Rajas P. ;

Kouzani, Abbas Z. ;

Walder, Ken ;

Berk, Michael ;

Tye, Susannah J. .

BIOLOGICAL PSYCHIATRY, 2015, 77 (09)

[44] Long-Term High Frequency Deep Brain Stimulation of the Nucleus Accumbens Drives Time-Dependent Changes in Functional Connectivity in the Rodent Limbic System [J].

Ewing, Samuel G. ;

Grace, Anthony A. .

BRAIN STIMULATION, 2013, 6 (03) :274-285

[45] Administration of the D2 Dopamine Receptor Antagonist Sulpiride into the Shell, but not the Core, of the Nucleus Accumbens Attenuates Cocaine Priming-Induced Reinstatement of Drug Seeking [J].

Sharon M Anderson ;

Heath D Schmidt ;

R Christopher Pierce .

Neuropsychopharmacology, 2006, 31 :1452-1461

[46] Administration of the D2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking [J].

Anderson, Sharon M. ;

D Schmidt, Heath ;

Pierce, R. Christopher .

NEUROPSYCHOPHARMACOLOGY, 2006, 31 (07) :1452-1461

[47] Failure to suppress low-frequency neuronal oscillatory activity underlies the reduced effectiveness of random patterns of deep brain stimulation [J].

McConnell, George C. ;

So, Rosa Q. ;

Grill, Warren M. .

JOURNAL OF NEUROPHYSIOLOGY, 2016, 115 (06) :2791-2802

[48] LOW-FREQUENCY DEEP BRAIN STIMULATION OF THE SUBTHALAMIC NUCLEUS MAINTAINS COGNITIVE CONTROL [J].

Cole, Rachel ;

Cavanagh, James ;

Singh, Arun ;

Wessel, Jan ;

Espinoza, Arturo ;

Yeager, Brooke ;

Greenlee, Jeremy ;

Narayanan, Nandakumar .

PSYCHOPHYSIOLOGY, 2022, 59 :S88-S88

[49] Comparison of hippocampal Deep Brain Stimulation with high (130 Hz) and low frequency (5 Hz) on afterdischarges in kindled rats [J].

Wyckhuys, Tine ;

Raedt, Robrecht ;

Vonck, Kristi ;

Wadman, Wytse ;

Boon, Paul .

EPILEPSY RESEARCH, 2010, 88 (2-3) :239-246

[50] Investigating a role of orexin and 'cocaine- and amphetamine-regulated transcript' in the nucleus accumbens shell in binge eating of male rats and the relationship with impulsivity [J].

Schuller, Julia ;

Koch, Michael .

PHYSIOLOGY & BEHAVIOR, 2022, 257

← 1 2 3 4 5 →