Therapy-Related Trilineage Mixed Phenotype Acute Leukemia Treated with Venetoclax and Azacitidine

被引:0
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作者
Yamamoto, Jotaro [1 ]
Yamaguchi, Kyosuke
Watanabe, Otoya
Kageyama, Kosei
Taya, Yuki
Kaji, Daisuke
Nishida, Aya
Uruga, Hironori
Takagi, Shinsuke
Ishiwata, Kazuya
Yamamoto, Hisashi
Masuda, Akiko
Takazawa, Yutaka
Yamamoto, Go
Mori, Yuki
Uchida, Naoyuki
Wake, Atsushi
机构
[1] Toranomon Hosp Kajigaya, Dept Hematol, Kawasaki, Japan
关键词
Mixed phenotype acute leukemia (MPAL); Myeloid neoplasm post cytotoxic therapy; Venetoclax; Azacitidine; Cord blood transplantation; STEM-CELL TRANSPLANTATION; MYELOID NEOPLASMS;
D O I
10.2169/internalmedicine.4898-24
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This is the first report of therapy-related mixed-phenotype acute leukemia (MPAL) characterized by B-cell, T-cell, and myeloid lineage phenotypes. A 68-year-old man, who was in complete remission after chemoradiotherapy for recurrent esophageal cancer, developed bacterial pneumonia with increasing blasts in the peripheral blood, and a subsequent bone marrow biopsy revealed 85.2% blasts. A flow cytometric analysis revealed cytMPO+, CD19+, cytCD22+, and cytCD3+ markers. The patient was diagnosed with therapy-related MPAL (B/T/myeloid lineage). After the initiation of venetoclax and azacitidine, the patient achieved complete remission, and cord blood transplantation was performed. This case provides novel insights into the therapeutic options for therapy-related trilineage MPAL treatment.
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页数:6
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