Scandium(III) Triflate Catalyzed Reductive Etherification of Carbonyl Compounds with Alcohols Using 1,1,3,3-Tetramethyldisiloxane as the Reducing Agent

被引：0

作者：

Nobuta, Tomoya ^{[1
]}

Yamagiwa, Noriyuki ^{[1
]}

Mineno, Tomoko ^{[1
]}

机构：

[1] Takasaki Univ Hlth & Welf, Fac Pharm, 60 Nakaorui, Takasaki, Gumma 3700033, Japan

来源：

SYNLETT | 2025年

关键词：

reduction; etherification; carbonyl compounds; ethers; scandium triflate catalysis; hydrosilanes; SILANE REDUCTIONS; ACIDIC MEDIA; SYMMETRICAL ETHERS; LEWIS ACIDITY; STEREOSELECTIVE CONSTRUCTION; ORGANOSILANE REDUCTIONS; FACILE CONVERSION; ALDEHYDES; KETONES; TRIALKYLSILANES;

D O I：

10.1055/a-2493-7449

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, we present a straightforward protocol for the reductive etherification of carbonyl compounds with alcohols using acatalytic amount of scandium(III) triflate [Sc(OTf)3] and 1,1,3,3-te-tramethyl disiloxane to produce non symmetrical ethers. The reaction proceeds under mild room-temperature conditions and accommodatesa broad range of substrates, including alpha,beta-unsaturated aldehydes, yielding the desired products in good to excellent yields. Notably, the cata-lyst loading of Sc(OTf)3 could be reduced to 0.1 mol%

引用

页数：6

共 30 条

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