Development and validation of a novel endoplasmic reticulum stress-related lncRNA signature in laryngeal squamous cell carcinoma

被引：0
作者：
Pan, Xiazhi [1 ]
Che, Qin [2 ]
Liu, Duanshali [1 ]
Xie, Yingli [2 ]
Li, Beicheng [2 ]
Zhang, Shanshan [2 ]
Li, Tian [3 ]
Li, Gege [2 ]
Li, Xiaohan [2 ]
Zheng, Qiuchen [2 ]
Zhao, Kai [2 ]
Liu, Mingbo [1 ,2 ,4 ,5 ]
机构：
[1] Shandong Second Med Univ, Sch Clin Med, Weifang 261042, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Hainan Hosp, Dept Otolaryngol Head & Neck Surg, Sanya 572013, Peoples R China
[3] Tianjin Med Univ, Tianjin Nankai Hosp, Inst Integrat Med Acute Abdominal Dis, Tianjin Key Lab Acute Abdomen Dis Associated Organ, 8 Changjiang Ave, Tianjin 300100, Peoples R China
[4] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 6, Senior Dept Otolaryngol Head & Neck Surg, Beijing 100048, Peoples R China
[5] Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Otolaryngol Dis, Beijing 100853, Peoples R China
来源：
SCIENTIFIC REPORTS | 2025年 / 15卷 / 01期
关键词：
Laryngeal squamous cell carcinoma; Prognostic model; Endoplasmic reticulum stress; LncRNA; CANCER; EXPRESSION; SURVIVAL; B7-H3;
D O I：
10.1038/s41598-025-96576-5
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Endoplasmic reticulum stress (ERS) is an intracellular process in which improperly folded proteins lead to a cellular stress response. How endoplasmic reticulum stress contributes to the onset and progression of laryngeal squamous cell carcinoma remains unclear. Our research aimed to find an ERS signature to forecast the prognosis of laryngeal squamous cell carcinoma and to investigate its potential biological functions. LSCC sample data obtained from The Cancer Genome Atlas (TCGA) database were co-expressed with ERS- related genes, and then a prognostic signature on the basis of endoplasmic reticulum stress- related lncRNAs (ERS-related lncRNAs) was constructed by differential analysis and Cox regression analysis. Survival analysis, TMB, consensus cluster analysis, drug sensitivity analysis, immune analysis and clinical drug prediction were carried out on the model. Finally, the function of LHX1-DT was verified by in vitro experiments. From the TCGA-LSCC cohort, 35 significantly different ERS-related lncRNAs were identified. A prognostic signature consisting of three lncRNAs (AC110611.2, LHX1-DT, and AL157373.2) was identified. Kaplan-Meier analysis demonstrated the predictive ability of the model for overall survival. Calibration curves and receiver operating characteristic curves were validated and showed high predictive accuracy. Ultimately, the experimental results verified the expression of LHX1-DT in LSCC.
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页数：19
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