Organocatalytic Dearomatization of β-Naphthols through a 1,6-Conjugated Addition of Alkynyl 7-Methylene-7H-indoles Formed In Situ

被引：0

作者：

Kang, Shengfu ^{[1
]}

Liu, Xiaohong ^{[1
]}

Zhang, Yi ^{[1
]}

Fang, Fang ^{[2
]}

Li, Wenjun ^{[1
]}

Li, Pengfei ^{[2
]}

机构：

[1] Qingdao Univ, Sch Pharm, Dept Med Chem, Qingdao 266021, Shandong, Peoples R China

[2] Southern Univ Sci & Technol SUSTech, Coll Sci, Guangming Adv Res Inst, Dept Chem,Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2025年 / 367卷 / 01期

关键词：

Addition; Allenes; Dearomatization; Indolylmethanol; Organocatalysis; CATALYTIC ASYMMETRIC DEAROMATIZATION; ENANTIOSELECTIVE SYNTHESIS; METAL CATALYSIS; ACID; CONSTRUCTION; ALLENES; REGIO;

D O I：

10.1002/adsc.202401173

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Organocatalytic dearomatization of beta-naphthols has been achieved via a 1,6-conjugated addition of 2-naphthols to alkynyl 7-methylene-7H-indoles in situ generated from alpha-(7-indolyl)methanols. In the presence of racemic phosphoric acid, a series of tetrasubstituted allenes was obtained in high yields. Particularly, with the aid of chiral phosphoric acid, asymmetric dearomatization of beta-naphthols was investigated, affording axially chiral tetrasubstituted allenes with moderate enantioselectivity.

引用

页数：6

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