Antibacterial Biocomposite Based on Chitosan/Pluronic/Agarose Noncovalent Hydrogel: Controlled Drug Delivery by Alginate/Tetracycline Beads System

被引:3
作者
Abdollahi, Hossein [1 ]
Amiri, Saber [2 ]
Amiri, Farzaneh [3 ]
Moradi, Somayeh [1 ]
Zarrintaj, Payam [4 ]
机构
[1] Urmia Univ, Fac Engn, Dept Polymer Engn, Orumiyeh 5756151818, Iran
[2] Urmia Univ, Fac Agr, Dept Food Sci & Technol, Orumiyeh 5756151818, Iran
[3] Tabriz Univ Med Sci, Fac Pharm, Dept Pharmaceut, Tabriz 5166653431, Iran
[4] Univ Montana, Dept Biomed & Pharmaceut Sci, Missoula, MT 59812 USA
关键词
biocompatible polymer; composite hydrogel; antibacterial; wound dressing; sustained drug release; CHITOSAN; SCAFFOLDS; RELEASE; MICROSPHERES; DEGRADATION;
D O I
10.3390/jfb15100286
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Designing a wound dressing with controlled uptake, antibacterial, and proper biocompatibility is crucial for the appropriate wound healing process. In this study, alginate/tetracycline (Alg/TC) beads were produced and embedded into chitosan/pluronic/agarose semi-interpenetrating polymer network hydrogel, which serves as a potential biocompatible dressing for treating skin wounds. The effect of pluronic content on the porosity, swelling, mechanical characteristics, and degradation of the hydrogel was investigated. Furthermore, the impact of Alg beads on TC release was subsequently examined. In the absence of Alg beads, faster release was observed. However, after incorporating beads into the hydrogels, the release was sustained. Particularly, the hydrogel containing Alg beads exhibited a nearly linear release, reaching 74% after 2 days in acidic media. The antimicrobial activity and biocompatibility of the hydrogel were also evaluated to assess the capability of the TC-loaded hydrogels for wound dressing applications. The hydrogel demonstrated efficient antibacterial features against Gram-positive and Gram-negative bacteria. Additionally, the sample behavior was evaluated against exposure to yeast. Furthermore, based on biocompatibility studies using HFF2 cells, the TC-loaded hydrogel exhibited remarkable biocompatibility. Overall, this novel composite hydrogel shows remarkable biocompatibility and antibacterial activities which can be used as a great potential wound dressing to prevent wound infections due to its effective inhibition of bacterial growth.
引用
收藏
页数:22
相关论文
共 45 条
[1]   Formulation strategies to modulate drug release from poloxamer based in situ gelling systems [J].
Abdeltawab, Hani ;
Svirskis, Darren ;
Sharma, Manisha .
EXPERT OPINION ON DRUG DELIVERY, 2020, 17 (04) :495-509
[2]   Kinetics of thermal degradation, adhesion and dynamic-mechanical properties of flexible polyamine-epoxy systems [J].
Abdollahi, Hossein ;
Samadi, Ali ;
Amiri, Farzaneh ;
Mousapour-Khaneshan, Vahid ;
Zarrintaj, Payam ;
Kavanlouei, Majid .
JOURNAL OF POLYMER RESEARCH, 2022, 29 (09)
[3]   New synthesis processes of polyetheramines: Comparison of three different developed amination routes [J].
Abdollahi, Hossein ;
Salimi, Ali ;
Barikani, Mehdi ;
Zeynizadeh, Behzad .
MATERIALS AND MANUFACTURING PROCESSES, 2017, 32 (11) :1296-1303
[4]   Thermosensitive Chitosan-Based Injectable Hydrogel as an Efficient Anticancer Drug Carrier [J].
Ahsan, Anam ;
Farooq, Muhammad Asim ;
Parveen, Amna .
ACS OMEGA, 2020, 5 (32) :20450-20460
[5]   Poloxamer 407/188 binary thermosensitive hydrogels as delivery systems for infiltrative local anesthesia: Physico-chemical characterization and pharmacological evaluation [J].
Akkari, Alessandra C. S. ;
Boava Papini, Juliana Z. ;
Garcia, Gabriella K. ;
Dias Franco, Margareth K. K. ;
Cavalcanti, Leide P. ;
Gasperini, Antonio ;
Alkschbirs, Melissa Inger ;
Yokaichyia, Fabiano ;
de Paula, Eneida ;
Tofoli, Giovana R. ;
de Araujo, Daniele R. .
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2016, 68 :299-307
[6]   Conductive hydrogel based on chitosan-aniline pentamer/gelatin/agarose significantly promoted motor neuron-like cells differentiation of human olfactory ecto-mesenchymal stem cells [J].
Bagher, Zohreh ;
Atoufi, Zhaleh ;
Alizadeh, Rafieh ;
Farhadi, Mohammad ;
Zarrintaj, Payam ;
Moroni, Lorenzo ;
Setayeshmehr, Mohsen ;
Komeili, Ali ;
Kamrava, S. Kamran .
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2019, 101 :243-253
[7]   Supermacroprous chitosan-agarose-gelatin cryogels: in vitro characterization and in vivo assessment for cartilage tissue engineering [J].
Bhat, Sumrita ;
Tripathi, Anuj ;
Kumar, Ashok .
JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2011, 8 (57) :540-554
[8]   Effect of intercalated chitosan/clay nanostructures on concentrated pluronic F127 solution: A FTIR-ATR, DSC and rheological study [J].
Branca, Caterina ;
Khouzami, Khaoula ;
Wanderlingh, Ulderico ;
D'Angelo, Giovanna .
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2018, 517 :221-229
[9]   Simple Agarose-Chitosan Gel Composite System for Enhanced Neuronal Growth in Three Dimensions [J].
Cao, Zheng ;
Gilbert, Ryan J. ;
He, Wei .
BIOMACROMOLECULES, 2009, 10 (10) :2954-2959
[10]   Chitosan-Based Aerogel Membrane for Robust Oil-in-Water Emulsion Separation [J].
Chaudhary, Jai Prakash ;
Vadodariya, Nilesh ;
Nataraj, Sanna Kotrappanavar ;
Meena, Ramavatar .
ACS APPLIED MATERIALS & INTERFACES, 2015, 7 (44) :24957-24962