In Vivo Test to Evaluate the Cytotoxicity and Genotoxicity of Natural Zeolite (NZ) Functionalized with Silver Nanoparticles (NZ-AgNPs) on Erythrocytes of Yellowtail Tetra Fish Astyanax lacustris

被引：0
作者：
da Silva, Josiane Rodrigues Rocha [1 ]
de Andrade, Camila Oliveira [1 ]
Ribeiro, Anna Carla [1 ,2 ]
Macruz, Paula Derksen [3 ]
Duarte, Elizabeth da Costa Neves FernandesAlmeida [2 ]
Bergamasco, Rosangela [4 ]
de Brito Portela-Castro, Ana Luiza [1 ,5 ]
Fernandes, Carlos Alexandre [1 ,5 ]
机构：
[1] Univ Estadual Maringa, Dept Biotechnol Genet & Cell Biol, Grad Program Environm Biotechnol, Maringa, PR, Brazil
[2] Univ Lisbon, Sch Agr, Linking Landscape Environm Agr & Food, Lisbon, Portugal
[3] Univ Estadual Maringa, Dept Chem, Biomol & Mass Spectrometry Lab, Maringa, PR, Brazil
[4] Univ Estadual Maringa, Dept Chem Engn, Maringa, PR, Brazil
[5] Univ Estadual Maringa, Biol Sci Ctr, Limnol Ichthyol & Aquaculture Res Nucleus NUPELIA, Maringa, PR, Brazil
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 2025年 / 203卷 / 07期
关键词：
Nanoparticles; Natural zeolites; Toxicity; Comet assay; Fish; SHORT-TERM EXPOSURE; ANTIMICROBIAL PROPERTIES; BACTERICIDAL ACTIVITY; ANTIBACTERIAL; CLINOPTILOLITE; OXIDE; AG; BEHAVIOR; AGENT;
D O I：
10.1007/s12011-024-04451-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Silver nanoparticles (AgNPs) have unique properties such as chemical stability, malleability, flexibility, high electrical and thermal conductivity, and catalytic activity, making them suitable for various applications. However, they also pose potential toxicity and environmental contamination risks. Natural zeolites (NZs) are considered excellent inorganic support for reducing the toxicity of AgNPs. The scope of this study was to carry out a comparative assessment of the cytotoxic and genotoxic effects of NZ, NZ functionalized with silver nanoparticles (NZ-AgNPs), and commercial AgNPs on fish Astyanax lacustris. Micronucleus (MN) test, cellular morphological change (CMC) test, and the comet assay were used to assess the effects of the nanoparticles. A. lacustris specimens were exposed to a concentrations of 0.1 mg l-1 in the NZs, NZ-AgNPs, and commercial AgNPs for 96 h during the experiment. The results showed no significant difference between the negative control and NZ. Moreover, NZ-AgNPs exhibited reduced toxicities compared to commercial AgNPs, which caused higher levels of alterations and cellular damage. The study concluded that NZs effectively reduced cytotoxicity/genotoxicity in A. lacustris specimens when used to support AgNPs.
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收藏
页码：3884 / 3895
页数：12
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