O-GlcNAcylation dictates pyroptosis

被引：1

作者：

Lang, Yue ^{[1
,2
,3
]}

Li, Jincheng ^{[3
]}

Zhang, Leiliang ^{[1
,2
,3
]}

机构：

[1] Shandong First Med Univ, Dept Clin Lab Med, Affiliated Hosp 1, Jinan, Shandong, Peoples R China

[2] Shandong Prov Qianfoshan Hosp, Jinan, Shandong, Peoples R China

[3] Shandong First Med Univ & Shandong Acad Med Sci, Sch Clin & Basic Med Sci, Dept Pathogen Biol, Jinan, Shandong, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

基金：

中国国家自然科学基金;

关键词：

pyroptosis; O-GlcNAcylation; GSDMD; GSDME; NLRP3; NF-KAPPA-B; NLRP3; INFLAMMASOME; GLCNAC TRANSFERASE; GLYCOSYLATION/O-PHOSPHORYLATION; CELL-DEATH; ACTIVATION; NEK7; INHIBITOR; PATHWAY;

D O I：

10.3389/fimmu.2024.1513542

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

O-GlcNAcylation is a dynamic post-translational modification involving the attachment of N-acetylglucosamine to serine and threonine residues. This review emphasizes its role in regulating the signaling pathways of pyroptosis. Specifically, the O-GlcNAcylation of GSDMD is linked to the modulation of pyroptosis, suggesting that enhancing O-GlcNAcylation of GSDMD could be crucial for improving hypoperfusion in sepsis. Additionally, GSDME, another member of the gasdermin family, facilitates macrophage pyroptosis through O-GlcNAcylation induced by high glucose levels in the context of periodontitis. The review also examines the effects of O-GlcNAcylation on the NLRP3 inflammasome and its regulators, including NEK7 and NF-kappa B. Overall, this review emphasizes the role of O-GlcNAcylation in the pathogenesis of conditions such as sepsis, periodontitis, and osteoarthritis, identifying potential therapeutic targets for managing inflammatory responses through its targeted modulation.

引用

页数：9

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