Roles of Lipoxygenases in Cardiovascular Diseases

被引：0
作者：
Liu, Ting [1 ,2 ,4 ]
Ai, Ding [1 ,2 ,3 ]
机构：
[1] Tianjin Med Univ, Key Lab Immune Microenvironm & Dis, Minist Educ, Tianjin 300070, Peoples R China
[2] Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin 300070, Peoples R China
[3] Tianjin Med Univ, Hosp 2,Prov & Minist Cosponsored Collaborat Innova, Tianjin Inst Cardiol,Natl Clin Res Ctr Blood Dis,K, Natl Clin Res Ctr Blood Dis,State Key Lab Expt Hem, Tianjin 300070, Peoples R China
[4] Tianjin Med Univ, Dept Cardiol, Gen Hosp, 154 Anshan Rd, Tianjin 300052, Peoples R China
来源：
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2025年
基金：
中国国家自然科学基金;
关键词：
Lipoxygenase; Arachidonic acid; Leukotrienes; Cardiovascular diseases; ISCHEMIA-REPERFUSION INJURY; LOW-DENSITY-LIPOPROTEIN; POLYUNSATURATED FATTY-ACIDS; HUMAN-ENDOTHELIAL-CELLS; LIPID MEDIATORS; MYOCARDIAL-INFARCTION; LEUKOTRIENE B-4; 5-LIPOXYGENASE-ACTIVATING PROTEIN; MACROPHAGE; 12/15-LIPOXYGENASE; RESOLVING INFLAMMATION;
D O I：
10.1007/s12265-025-10605-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Lipoxygenases (LOXs) are a family of dioxygenases that catalyze the peroxidation of polyunsaturated fatty acids, such as linoleic acid and arachidonic acid, initiating the synthesis of bioactive lipid mediators. The LOX-mediated production of these bioactive molecules in various cell types plays a critical role in the pathophysiology of cardiovascular diseases, including atherosclerosis, hypertension, and myocardial ischemia-reperfusion injury. In this review, we summarize the roles of LOXs and their products in different cardiovascular cells and conditions, offering valuable insights may contribute to the development of novel therapeutic strategies for cardiovascular diseases.
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页数：12
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