Myelin oligodendrocyte glycoprotein antibody-associated disease mimicking neuromyelitis optica spectrum disorder

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and neuromyelitis optica spectrum disorders (NMOSD) are two rare autoimmune inflammatory demyelinating diseases involving the central nervous system, which are often seen with combined involvement of the optic nerve and spinal cord. MOGAD can be confused with multiple sclerosis or NMOSD, due to its clinical presentation that may be similar and its characteristic to progress with habitual attacks. Although the clinical course of the above-mentioned three diseases is similar, their diagnosis and management are different. We hereby report a case which presented with predominant features of NMOSD but was later diagnosed as MOGAD, with strongly positive results for serum anti-myelin oligodendrocyte glycoprotein IgG antibody.