The Correlation Between Urinary AlbuminCreatinine Ratio and The Stage of Chronic Kidney Disease in Type 2 Diabetes Mellitus Patients in Bali

被引：0

作者：

Lestarini, Asri ^{[1
]}

Aryastuti, Sri Agung ^{[1
]}

Witari, Ni Putu Diah ^{[1
]}

Dewi, Ni Wayan Erly Sintya ^{[1
]}

Permatananda, Pande Ayu Naya Kasih ^{[1
]}

Cahyawati, Putu Nita ^{[1
]}

Sutarka, Wayan ^{[2
]}

Sastrawan, I. Made Agus ^{[2
]}

Wardani, Ni Wayan Sri ^{[3
]}

Saputra, Wayan Eka ^{[3
]}

机构：

[1] Univ Warmadewa, Fac Med & Hlth Sci, Denpasar, Indonesia

[2] Tabanan Hosp, Bali, Indonesia

[3] Sanjiwani Hosp, Bali, Indonesia

来源：

BALI MEDICAL JOURNAL | 2024年 / 13卷 / 02期

关键词：

urinary albumin-creatinine ratio; diabetes mellitus; GLOMERULAR-FILTRATION-RATE; CLINICAL-SIGNIFICANCE; HYPERFILTRATION; PREVALENCE; FREQUENCY; ADULTS; GFR;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: Diabetic nephropathy is one of the complications caused by metabolic disease, which could lead to renal failure. A marker that can potentially be used for the early detection of diabetic nephropathy is the urinary albumin-creatinine ratio (uACR). This study aimed to measure the correlation between uACR and the stage of renal failure. Methods: Cross-sectional study was conducted from March until August 2018. Participants were clinically examined, and blood and urine were taken. The stages of renal failure were determined by estimated Glomerular Filtration Rate (eGFR). Data was statistically analyzed using one-way ANOVA and Pearson correlation. Results: Seventy-nine participants were eligible for inclusion in data analysis. The participants were grouped into 5 stages of renal failure. Urinary albumin-creatinine ratios in stages 1,2,3,4,5 were 204.9, 125.9, 474.9, 604.7, and 2895.6, respectively. Posthoc analysis showed significant differences in uACR between stage 5 and stage 1,2,3, respectively (p<0.05). Significant correlations were found in uACR with SC (r 0.354, p 0.001), BUN (r 0.244, p 0.032) and eGFR (r-0.345, p 0.02) respectively. Conclusion: Urinary albumin-creatinine ratio had a positive correlation with serum creatinine and blood urea nitrogen, while had a negative correlation with estimated glomerular filtration rate.

引用

页数：134

共 28 条

[1]

Alhajim SA, 2018, Am J Lab Med, V3, P48, DOI [10.11648/j.ajlm.20180306.11, DOI 10.11648/J.AJLM.20180306.11]

[2]

[Anonymous], 2019, DIABETES CARE, V42, pS1, DOI [10.2337/dc20-Sint, 10.2337/dc19-Sint01, 10.2337/dc19-SINT01, 10.2337/dc16-S001, 10.2337/dc20-SINT]

[3]

Aryastuti SA, 2022, BIOMED PHARMACOL J, V15, P269, DOI DOI 10.13005/bpj/2363

[4] Simvastatin Improves Renal Function and Glomerulosclerosis in Ischemic-reperfusion Injury [J].