Non-coding RNAs in urinary bladder cancer microenvironment: Diagnostic, therapeutic, and prognostic perspective

被引：0
作者：
El Saftawy, Enas A. [1 ,2 ]
Aboulhoda, Basma Emad [3 ]
Abdelkhalek, Marwa Ali [4 ,5 ]
Alghamdi, Mansour A. [6 ,7 ,8 ]
Alhariry, Nashwah Samir [9 ]
机构：
[1] Cairo Univ, Fac Med, Dept Med Parasitol, Cairo, Egypt
[2] Armed Forces Coll Med, Dept Med Parasitol, Cairo, Egypt
[3] Cairo Univ, Fac Med, Dept Anat & Embryol, Cairo, Egypt
[4] Ain Shams Univ, Fac Med, Med Biochem & Mol Biol, Cairo, Egypt
[5] Armed Forces Coll Med, Dept Med Biochem & Mol Biol, Cairo, Egypt
[6] King Khalid Univ, Cent Labs, POB 960, Abha, Saudi Arabia
[7] King Khalid Univ, Coll Med, Dept Anat, Abha 62529, Saudi Arabia
[8] King Khalid Univ, Ctr Med & Hlth Res, Genom & Personalized Med Unit, Abha 62529, Saudi Arabia
[9] Suez Univ, Fac Med, Dept Pathol, Suez, Egypt
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2025年 / 266卷
关键词：
Urinary bladder cancer; Noncoding RNAs; MiRNAs; LncRNAs; SnoRNAs; PIWI-interacting RNAs; Mitochondrial RNAs; Circular; Schistosoma haematobium; EPITHELIAL-MESENCHYMAL TRANSITION; CELL-PROLIFERATION; TUMOR-GROWTH; PROMOTES; EXPRESSION; INVASION; MIGRATION; METASTASIS; CHEMORESISTANCE; AGGRESSIVENESS;
D O I：
10.1016/j.prp.2025.155815
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Urinary bladder cancer (UBC) is the ninth most common cancer worldwide. Despite the reliance of UBC therapy on definite pathological grading and classifications, the clinical response among patients varies widely. The molecular basis of this type of cancer appeals to considerable research; hence, new diagnostic and therapeutic options are introduced. Convenient keywords were searched in Google Scholar, PubMed, the Egyptian Knowledge Bank (EKB), and Web of Science. The recent era of UBC research is concerned with non-coding RNAs (ncRNAs), predominantly, microRNAs (miRNAs) and long non-coding RNA (lncRNAs). In addition, snoRNAs, PIWI-interacting RNAs, mitochondrial RNAs, circular, and Schistosoma haematobium-related ncRNAs appeared to contribute to the pathogenesis of the UBC. This review underscored the recently studied ncRNAs and their importance in the pathogenesis of UBC. Besides, we introduced the prospectives regarding their diagnostic, therapeutic, and prognostic significance in UBC clinical settings. Conclusion. Oncogenic and oncosuppressor ncRNAs' definite balances and interaction within the TME of UBC are key players in the fate of the tumor. Thus, profiling ncRNA in-depth inspects the TME of the UBC for better clinical insights.
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页数：13
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