Tetrasubstituted Chromanone Synthesis by a Tandem Oxa-Michael/Michael Addition Reaction of 2-Hydroxyacetophenones and Alkynyl Nitriles

被引：0
|
作者：
Kumari, Chandresh [1 ]
Sahoo, Narendra Prasad [1 ]
Kumar, Madan [1 ]
Goswami, Avijit [1 ]
机构：
[1] Indian Inst Technol Ropar, Dept Chem, Rupnagar 140001, Punjab, India
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 28卷 / 03期
关键词：
4-chromanones; Alkynyl nitriles; Oxa-michael addition reactions; Michael addition reactionss; 2-hydroxy acetophenones; ASYMMETRIC CATALYSIS; REDUCTIVE UMPOLUNG; DERIVATIVES; CHROMAN-4-ONE; FLAVANONES; ACIDS; CYCLIZATION; SELECTIVITY; CHROMONE; DIYNES;
D O I：
10.1002/ejoc.202401061
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient transition metal-free approach for the synthesis of chroman-4-ones via double conjugate addition of 2-hydroxyacetophenones on alkynyl nitriles utilizing NaH as a base has been realized. This operationally simple protocol offers library of 4-chromanones in moderate to good yields.
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页数：5
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