Crosstalk between lactate and tumor-associated immune cells: clinical relevance and insight

被引：5

作者：

Sun, Kemin ^{[1
,2
,3
,4
]}

Shen, Ye ^{[5
]}

Xiao, Xiang ^{[1
,2
,3
,4
]}

Xu, Hao ^{[1
,2
,3
,4
]}

Zhang, Quanli ^{[1
,2
,3
,6
,7
,8
,9
]}

Li, Ming ^{[1
,2
,3
,4
]}

机构：

[1] Nanjing Med Univ, Affiliated Canc Hosp, Dept Thorac Surg, Nanjing, Jiangsu, Peoples R China

[2] Jiangsu Canc Hosp, Nanjing, Jiangsu, Peoples R China

[3] Jiangsu Inst Canc Res, Collaborat Innovat Ctr Canc Personalized Med, Jiangsu Key Lab Mol & Translat Canc Res, Nanjing, Jiangsu, Peoples R China

[4] Nanjing Med Univ, Sch Clin Med 4, Nanjing, Jiangsu, Peoples R China

[5] China Pharmaceut Univ, Sch Tradit Chinese Med, Nanjing, Peoples R China

[6] Nanjing Med Univ, Jiangsu Canc Hosp, Dept Sci Res, Nanjing, Jiangsu, Peoples R China

[7] Nanjing Med Univ, Affiliated Canc Hosp, Nanjing, Jiangsu, Peoples R China

[8] Jiangsu Inst Canc Res, Jiangsu Key Lab Mol & Translat Canc Res, Nanjing, Jiangsu, Peoples R China

[9] China Pharmaceut Univ, Dept Clin Pharm, Nanjing, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2024年 / 14卷

关键词：

lactate; tumor microenvironment; Warburg effect; immunosuppression; cancer immunotherapy; MONOCARBOXYLATE TRANSPORTERS; SUPPRESSOR-CELLS; DOWN-REGULATION; DEHYDROGENASE; EXPRESSION; MACROPHAGES; METABOLISM; ACTIVATION; PROGRESSION; METASTASES;

D O I：

10.3389/fonc.2024.1506849

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lactate, which was traditionally viewed as a metabolic byproduct of anaerobic glycolysis, has emerged as a significant signaling molecule involved in the development of tumors. Current studies highlight its dual function, where it not only fuels tumor development but also modulates immune responses. Lactate has an effect on various tumor-associated immune cells, promoting immunosuppressive conditions that facilitate tumor growth and immune evasion. This phenomenon is strongly associated with the Warburg effect, a metabolic shift observed in many cancers that favors glycolysis over oxidative phosphorylation, resulting in elevated lactate production. Exploring the complex interplay between lactate metabolism and tumor immunity provides a novel understanding regarding the mechanisms of tumor immune evasion and resistance to therapies. This review discusses the unique biology of lactate in the TME, its impact on immune cell dynamics, and its potential as a tumor treatment target.

引用

页数：13

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