Lipoteichoic Acid Rescued Age-Related Bone Loss by Enhancing Neuroendocrine and Growth Hormone Secretion Through TLR2/COX2/PGE2 Signalling Pathway

被引：1
作者：
Liu, Zixian [1 ,2 ,3 ,4 ]
Lin, Zexin [1 ,2 ]
Chen, Yingqi [1 ,2 ]
Lu, Mincheng [5 ]
Hong, Weisheng [1 ,2 ]
Yu, Bin [1 ,2 ]
Liu, Guanqiao [1 ,2 ]
机构：
[1] Southern Med Univ, Nanfang Hosp, Dept Orthopaed, Guangzhou, Peoples R China
[2] Southern Med Univ, Nanfang Hosp, Guangdong Prov Key Lab Bone & Cartilage Regenerat, Guangzhou, Peoples R China
[3] Lanzhou Univ, Hosp 2, Lanzhou, Peoples R China
[4] Lanzhou Univ, Clin Med Sch, Lanzhou, Peoples R China
[5] Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Dept Orthoped, Shenzhen, Peoples R China
来源：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2024年 / 28卷 / 23期
基金：
中国国家自然科学基金;
关键词：
bone loss; brain-bone; growth hormone; lipoteichoic acid; PGE2; OSTEOPOROSIS; MICROGLIA; E-2; CYCLOOXYGENASE-2; PROSTAGLANDIN-E2; TRANSCRIPTION; MACROPHAGES; RECEPTORS; FRACTURES; AXIS;
D O I：
10.1111/jcmm.70247
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The phenomenon of brain-bone crosstalk pertains to the intricate interaction and communication pathways between the central nervous system and the skeletal system. Disruption in brain-bone crosstalk, particularly in disorders such as osteoporosis, can result in skeletal irregularities. Consequently, investigating and comprehending this communication network holds paramount importance in the realm of bone disease prevention and management. In this study, we found that Staphylococcus aureus lipoteichoic acid promoted the conversion of arachidonic acid to PGE2 by interacting with TLR2 receptors acting on the surface of microglial cells in the pituitary gland, leading to the upregulation of COX-2 expression. Subsequently, PGE2 bound to the EP4 receptor of growth hormone-secreting cells and activated the intracellular CREB signalling pathway, promoting GH secretion and ameliorating age-related bone loss.
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页数：18
相关论文
共 83 条
[71]   Management of Osteoporosis in Men: A Narrative Review [J].
Vescini, Fabio ;
Chiodini, Iacopo ;
Falchetti, Alberto ;
Palermo, Andrea ;
Salcuni, Antonio Stefano ;
Bonadonna, Stefania ;
De Geronimo, Vincenzo ;
Cesareo, Roberto ;
Giovanelli, Luca ;
Brigo, Martina ;
Bertoldo, Francesco ;
Scillitani, Alfredo ;
Gennari, Luigi .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (24)
[72]   Short-Chain Fatty Acids Inhibit Growth Hormone and Prolactin Gene Transcription via cAMP/PKA/CREB Signaling Pathway in Dairy Cow Anterior Pituitary Cells [J].
Wang, Jian-Fa ;
Fu, Shou-Peng ;
Li, Su-Nan ;
Hu, Zhong-Ming ;
Xue, Wen-Jing ;
Li, Zhi-Qiang ;
Huang, Bing-Xu ;
Lv, Qing-Kang ;
Liu, Ju-Xiong ;
Wang, Wei .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (11) :21474-21488
[73]   Bone-derived PDGF-BB drives brain vascular calcification in male mice [J].
Wang, Jiekang ;
Fang, Ching-Lien ;
Noller, Kathleen ;
Wei, Zhiliang ;
Liu, Guanqiao ;
Shen, Ke ;
Song, Kangping ;
Cao, Xu ;
Wan, Mei .
JOURNAL OF CLINICAL INVESTIGATION, 2023, 133 (23)
[74]   Pulsed electromagnetic fields promote bone formation by activating the sAC-cAMP-PKA-CREB signaling pathway [J].
Wang, Yuan-Yuan ;
Pu, Xiu-Ying ;
Shi, Wen-Gui ;
Fang, Qing-Qing ;
Chen, Xin-Ru ;
Xi, Hui-Rong ;
Gao, Yu-Hai ;
Zhou, Jian ;
Xian, Cory J. ;
Chen, Ke-Ming .
JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (03) :2807-2821
[75]   Roles of the prostaglandin E2 receptors EP subtypes in Alzheimer's disease [J].
Wei, Li-Li ;
Shen, Yue-Di ;
Zhang, Ying-Chun ;
Hu, Xing-Yue ;
Lu, Pei-Ling ;
Wang, Li ;
Chen, Wei .
NEUROSCIENCE BULLETIN, 2010, 26 (01) :77-84
[76]   FGF2 positively regulates osteoclastogenesis via activating the ERK-CREB pathway [J].
Wen, Xin ;
Hu, Geng ;
Xiao, Xue ;
Zhang, Xinzhi ;
Zhang, Qiang ;
Guo, Hengjun ;
Li, Xianyao ;
Liu, Qingxin ;
Li, Haifang .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2022, 727
[77]   Endothelial cell prostaglandin E2 receptor EP4 is essential for blood pressure homeostasis [J].
Xu, Hu ;
Fang, Bingying ;
Du, Shengnan ;
Wang, Sailun ;
Li, Qingwei ;
Jia, Xiao ;
Bao, Chengzhen ;
Ye, Lan ;
Sui, Xue ;
Qian, Lei ;
Luan, Zhilin ;
Yang, Guangrui ;
Zheng, Feng ;
Wang, Nanping ;
Chen, Lihong ;
Zhang, Xiaoyan ;
Guan, Youfei .
JCI INSIGHT, 2020, 5 (13)
[78]   COX-2/PGE2 Pathway Inhibits the Ferroptosis Induced by Cerebral Ischemia Reperfusion [J].
Xu, Yunfei ;
Liu, Ying ;
Li, Kexin ;
Yuan, Dun ;
Yang, Shun ;
Zhou, Lin ;
Zhao, Yao ;
Miao, Shuying ;
Lv, Caihong ;
Zhao, Jie .
MOLECULAR NEUROBIOLOGY, 2022, 59 (03) :1619-1631
[79]   GRK2 Mediated Abnormal Transduction of PGE2-EP4-cAMP-CREB Signaling Induces the Imbalance of Macrophages Polarization in Collagen-Induced Arthritis Mice [J].
Yang, Xuezhi ;
Li, Susu ;
Zhao, Yingjie ;
Li, Siyu ;
Zhao, Tianjiao ;
Tai, Yu ;
Zhang, Bingjie ;
Wang, Xinwei ;
Wang, Chun ;
Chen, Jingyu ;
Wang, Qingtong ;
Zhang, Lingling ;
Xu, Dexiang ;
Chang, Yan ;
Wei, Wei .
CELLS, 2019, 8 (12)
[80]   Elevated plasma sclerostin is associated with high brain amyloid-β load in cognitively normal older adults [J].
Yuan, Jun ;
Pedrini, Steve ;
Thota, Rohith ;
Doecke, James ;
Chatterjee, Pratishtha ;
Sohrabi, Hamid R. ;
Teunissen, Charlotte E. ;
Verberk, Inge M. W. ;
Stoops, Erik ;
Vanderstichele, Hugo ;
Meloni, Bruno P. ;
Mitchell, Christopher ;
Rainey-Smith, Stephanie ;
Goozee, Kathryn ;
Tai, Andrew Chi Pang ;
Ashton, Nicholas ;
Zetterberg, Henrik ;
Blennow, Kaj ;
Gao, Junjie ;
Liu, Delin ;
Mastaglia, Frank ;
Inderjeeth, Charles ;
Zheng, Minghao ;
Martins, Ralph N. .
NPJ AGING, 2023, 9 (01)
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