Lipoteichoic Acid Rescued Age-Related Bone Loss by Enhancing Neuroendocrine and Growth Hormone Secretion Through TLR2/COX2/PGE2 Signalling Pathway

被引：1

作者：

Liu, Zixian ^{[1
,2
,3
,4
]}

Lin, Zexin ^{[1
,2
]}

Chen, Yingqi ^{[1
,2
]}

Lu, Mincheng ^{[5
]}

Hong, Weisheng ^{[1
,2
]}

Yu, Bin ^{[1
,2
]}

Liu, Guanqiao ^{[1
,2
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Dept Orthopaed, Guangzhou, Peoples R China

[2] Southern Med Univ, Nanfang Hosp, Guangdong Prov Key Lab Bone & Cartilage Regenerat, Guangzhou, Peoples R China

[3] Lanzhou Univ, Hosp 2, Lanzhou, Peoples R China

[4] Lanzhou Univ, Clin Med Sch, Lanzhou, Peoples R China

[5] Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Dept Orthoped, Shenzhen, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2024年 / 28卷 / 23期

基金：

中国国家自然科学基金;

关键词：

bone loss; brain-bone; growth hormone; lipoteichoic acid; PGE2; OSTEOPOROSIS; MICROGLIA; E-2; CYCLOOXYGENASE-2; PROSTAGLANDIN-E2; TRANSCRIPTION; MACROPHAGES; RECEPTORS; FRACTURES; AXIS;

D O I：

10.1111/jcmm.70247

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The phenomenon of brain-bone crosstalk pertains to the intricate interaction and communication pathways between the central nervous system and the skeletal system. Disruption in brain-bone crosstalk, particularly in disorders such as osteoporosis, can result in skeletal irregularities. Consequently, investigating and comprehending this communication network holds paramount importance in the realm of bone disease prevention and management. In this study, we found that Staphylococcus aureus lipoteichoic acid promoted the conversion of arachidonic acid to PGE2 by interacting with TLR2 receptors acting on the surface of microglial cells in the pituitary gland, leading to the upregulation of COX-2 expression. Subsequently, PGE2 bound to the EP4 receptor of growth hormone-secreting cells and activated the intracellular CREB signalling pathway, promoting GH secretion and ameliorating age-related bone loss.

引用

页数：18

共 83 条

[1] Muramyl dipeptide potentiates staphylococcal lipoteichoic acid induction of cyclooxygenase-2 expression in macrophages [J].

Ahn, Ki Bum ;

Jeon, Jun Ho ;

Baik, Jung Eun ;

Park, Ok-Jin ;

Kang, Seok-Seong ;

Yun, Cheol-Heui ;

Park, Jong-Hwan ;

Han, Seung Hyun .

MICROBES AND INFECTION, 2014, 16 (02) :153-160

[2] The microsomal prostaglandin E synthase-1/prostaglandin E2 axis induces recovery from ischaemia via recruitment of regulatory T cells [J].

Amano, Hideki ;

Eshima, Koji ;

Ito, Yoshiya ;

Nakamura, Masaki ;

Kitasato, Hidero ;

Ogawa, Fumihiro ;

Hosono, Kanako ;

Iwabuchi, Kazuya ;

Uematsu, Satoshi ;

Akira, Shizuo ;

Narumiya, Shuh ;

Majima, Masataka .

CARDIOVASCULAR RESEARCH, 2023, 119 (05) :1218-1233

[3] Lipoteichoic acid from Bifidobacterium animalis subsp. lactis BPL1: a novel postbiotic that reduces fat deposition via IGF-1 pathway [J].

Balaguer, Ferran ;

Enrique, Maria ;

Llopis, Silvia ;

Barrena, Marta ;

Navarro, Veronica ;

Alvarez, Beatriz ;

Chenoll, Empar ;

Ramon, Daniel ;

Tortajada, Marta ;

Martorell, Patricia .

MICROBIAL BIOTECHNOLOGY, 2022, 15 (03) :805-816

[4] Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis [J].

Chen, Hao ;

Hu, Bo ;

Lv, Xiao ;

Zhu, Shouan ;

Zhen, Gehua ;

Wan, Mei ;

Jain, Amit ;

Gao, Bo ;

Chai, Yu ;

Yang, Mi ;

Wang, Xiao ;

Deng, Ruoxian ;

Wang, Lei ;

Cao, Yong ;

Ni, Shuangfei ;

Liu, Shen ;

Yuan, Wen ;

Chen, Huajiang ;

Dong, Xinzhong ;

Guan, Yun ;

Yang, Huilin ;

Cao, Xu .

NATURE COMMUNICATIONS, 2019, 10 (1)

[5] Role of prostaglandin E2 in tissue repair and regeneration [J].

Cheng, Hui ;

Huang, Haoyan ;

Guo, Zhikun ;

Chang, Ying ;

Li, Zongjin .

THERANOSTICS, 2021, 11 (18) :8836-8854

[6] Lipoteichoic acid restrains macrophage senescence via β-catenin/FOXO1/REDD1 pathway in age-related osteoporosis [J].

Cheng, Weike ;

Fu, Yong ;

Lin, Zexin ;

Huang, Mouzhang ;

Chen, Yingqi ;

Hu, Yanjun ;

Lin, Qingrong ;

Yu, Bin ;

Liu, Guanqiao .

AGING CELL, 2024, 23 (03)

[7] IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain [J].

Chopra, Sahil ;

Giovanelli, Paolo ;

Alvarado-Vazquez, Perla Abigail ;

Alonso, Sara ;

Song, Minkyung ;

Sandoval, Tito A. ;

Chae, Chang-Suk ;

Tan, Chen ;

Fonseca, Miriam M. ;

Gutierrez, Silvia ;

Jimenez, Leandro ;

Subbaramaiah, Kotha ;

Iwawaki, Takao ;

Kingsley, Philip J. ;

Marnett, Lawrence J. ;

Kossenkov, Andrew V. ;

Crespo, Mariano Sanchez ;

Dannenberg, Andrew J. ;

Glimcher, Laurie H. ;

Romero-Sandoval, E. Alfonso ;

Cubillos-Ruiz, Juan R. .

SCIENCE, 2019, 365 (6450) :248-+

[8] The Pleiotropic Face of CREB FamilyTranscription Factors [J].

Chowdhury, Md. Arifur Rahman ;

An, Jungeun ;

Jeong, Sangyun .

MOLECULES AND CELLS, 2023, 46 (07) :399-413

[9] Regulation of Hepatic Metabolism and Cell Growth by the ATF/CREB Family of Transcription Factors [J].

Cui, Aoyuan ;

Ding, Dong ;

Li, Yu .

DIABETES, 2021, 70 (03) :653-664

[10] The Complex World of Regulation o f Pituitary Growth Hormone Secretion: The Role of Ghrelin, Klotho, and Nesfatins in It [J].

Devesa, Jesus .

FRONTIERS IN ENDOCRINOLOGY, 2021, 12

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