Multi-omics analysis reveals the neuroprotective effect of Atractylodis Rhizoma Alba extract against Parkinson's disease in mouse

被引：0
作者：
Kang, Sohi [1 ,2 ,3 ]
Lee, Sueun [4 ]
Moon, Byeong Cheol [4 ]
Song, Jun Ho [4 ,5 ]
Kim, Sung-Ho [2 ,3 ]
Moon, Changjong [2 ,3 ]
Lee, Soong-In [6 ]
Kim, Chul [7 ]
Kim, Joong Sun [2 ,3 ]
机构：
[1] Gyeongsang Natl Univ, Inst Hlth Sci, Coll Med, Dept Anat & Convergence Med Sci, Gwangju 52727, South Korea
[2] Chonnam Natl Univ, Coll Vet Med, Gwangju 61186, South Korea
[3] Chonnam Natl Univ, FOUR BK21 Program, Gwangju 61186, South Korea
[4] Korea Inst Oriental Med, Herbal Med Resources Res Ctr, 111 Geonjae Ro, Naju Si 58245, Jeollanam Do, South Korea
[5] Chungbuk Natl Univ, Dept Biol, Cheongju 28644, South Korea
[6] Dong Shin Univ, Coll Oriental Med, Dept Oriental Med Prescript, Naju Si 58245, Jeonranam Do, South Korea
[7] Korea Inst Oriental Med, KM Data Div, 1672 Yuseong Daero, Daejeon 34054, South Korea
来源：
JOURNAL OF TRADITIONAL CHINESE MEDICINE | 2024年 / 44卷 / 06期
关键词：
Parkinson disease; nerve degeneration; 1-methyl-4phenyl-1; 2; 3; 6-tetrahydropyridine; Atractylodis Rhizoma Alba; Methyl-seq; GENE-EXPRESSION; MODEL; MECHANISMS; DOPAMINE; EXTRACT; CANCER;
D O I：
暂无
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
OBJECTIVE: To assess Atractylodis Rhizoma Alba extract (ARE) neuroprotective function in 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice and related genes. METHODS: Examined mRNA-DNA methylation changes induced by ARE in MPTP-induced Parkinson's disease (PD) model's substantia nigra. RESULTS: ARE mitigated MPTP-induced motor impairment in rotarod and open field tests and preserved tyrosine hydroxylase-positive neuronal cells in substantia nigra and striatum. Genome RNA-Sequencing and Methyl-Sequencing in substantia nigra of vehicle/AREtreated MPTP-induced PD mice showed 84 differentially expressed genes (DEGs) and 1804 differentially methylated regions (DMRs). Upregulated genes involved zinc ion homeostasis, cilium protein localization, and transcription; downregulated genes linked to ephrin receptor signaling, somitogenesis, and gene expression regulation. Hyper/hypomethylated DMRs post-ARE treatment associated with Wnt signaling, mitochondrial organization, dopamine biosynthesis, and hindbrain development. No significant correlation between DEGs and methylated genes related to PD pathogenesis. CONCLUSION: This research has identified the epigenetic targets of ARE's therapeutic action and gives insight on how ARE protects neurons in Parkinson's disease. (c) 2024 JTCM. All rights reserved.
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页码：1111 / 1117
页数：7
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