Mechanical Properties and Decomposition Behavior of Compression Moldable Poly(Malic Acid)/α-Tricalcium Phosphate Hybrid Materials

被引:0
|
作者
Hara, Shuta [1 ]
Kojima, Akiko [2 ]
Furukawa, Atsushi [2 ]
Toyama, Takeshi [2 ]
Ikake, Hiroki [2 ]
Shimizu, Shigeru [2 ]
Kurita, Kimio [2 ]
机构
[1] Kanagawa Univ, Dept Mat & Life Chem, 3-6-1 Kanagawa Ku, Yokohama 2218686, Japan
[2] Nihon Univ, Coll Sci & Technol, Dept Mat & Appl Chem, 1-8-14 Kandasurugadai,Chiyoda Ku, Tokyo 1018308, Japan
关键词
Poly(malic acid); alpha-Tricalcium phosphate; Hybrid materials; The bone tissue material; ALPHA-TRICALCIUM PHOSPHATE; BETA-POLY(L-MALATE) PRODUCTION; POLY(ALPHA; BETA-MALIC ACID); PHYSARUM-POLYCEPHALUM; MOLECULAR-WEIGHT; CALCIUM; CERAMICS; TCP;
D O I
10.3390/polym17020147
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Calcified tissues in living organisms, such as bone, dentin, and enamel, often require surgical intervention for treatment. However, advances in regenerative medicine have increased the demand for materials to assist in regenerating these tissues. Among the various forms of calcium phosphate (CaP), tricalcium phosphate (TCP)-particularly its alpha-TCP form-stands out due to its high solubility and efficient calcium release, making it a promising candidate for bone regeneration applications. Nevertheless, its rapid dissolution rate presents challenges when used as a reinforcing agent. In this study, we developed a hybrid material composed of poly(malic acid) (PMA) and alpha-TCP to achieve controlled calcium release while maintaining mechanical strength. The hybrid materials were prepared using a compression molding method optimized to suppress the hydrolysis of PMA. The bond between the carboxyl group of PMA and alpha-TCP was confirmed through infrared (IR) spectroscopy. A calcium release test demonstrated that the interaction between PMA and alpha-TCP extends the dissolution period of both components. These findings indicate that PMA/alpha-TCP hybrid materials have significant potential for applications in bone tissue engineering.
引用
收藏
页数:10
相关论文
共 50 条
  • [21] Tuning Degradation and Mechanical Properties of Poly(l-lactic acid) with Biomass-Derived Poly(l-malic acid)
    Qianru Wanyan
    Yaxin Qiu
    Wenyuan Xie
    Defeng Wu
    Journal of Polymers and the Environment, 2020, 28 : 884 - 891
  • [22] Thermal, crystallization, mechanical and decomposition properties of poly(lactic acid) plasticized with poly(ethylene glycol)
    Wang, Bing
    Hina, Kanza
    Zou, Hantao
    Zuo, Danying
    Yi, Changhai
    JOURNAL OF VINYL & ADDITIVE TECHNOLOGY, 2018, 24 : E154 - E163
  • [23] Properties of a New Poly (L-Lactic Acid)/β-Tricalcium Phosphate (PLLA/β-TCP) Porous Scaffold in Vitro
    Zhang Ning
    Liang Xing
    Li Xiaoyu
    Tang Li
    Yin Guangfu
    Kang Yunqing
    RARE METAL MATERIALS AND ENGINEERING, 2008, 37 : 702 - 705
  • [24] Analytical prediction of hydrolysis behavior of tricalcium phosphate/poly-L-lactic acid composites in simulated body environment
    Kobayashi, Satoshi
    Yamaji, Shusaku
    ADVANCED COMPOSITE MATERIALS, 2014, 23 (03) : 211 - 223
  • [25] Effect of Nucleating Agent Tricalcium Phosphate on Degree of Crystallinity, Mechanical Properties and Degradation Properties of Poly(L-lactide-co-glycolide)
    Zhao N.
    Zhang T.
    Chen H.
    Ma Z.
    Ma, Zhigang (ma.zg@163.com), 2018, Sichuan University (34): : 91 - 98
  • [26] Mechanical behavior of hydroxyapatite-poly(lactic acid) hybrid porous scaffold
    Zusho, Yu
    Kobayashi, Satoshi
    Osada, Toshiko
    ADVANCED COMPOSITE MATERIALS, 2020, 29 (06) : 587 - 602
  • [27] Crosslinking characteristics of an injectable poly(propylenefumarate) β-tricalcium phosphate paste and mechanical properties of the crosslinked composite for use as a biodegradable bone cement
    Peter, SJ
    Kim, P
    Yasko, AW
    Yaszemski, MJ
    Mikos, AG
    BIOMATERIALS REGULATING CELL FUNCTION AND TISSUE DEVELOPMENT, 1998, 530 : 87 - 92
  • [28] Effect of in vitro hydrolysis on the compressive behavior and strain rates dependence of tricalcium phosphate/poly(L-lactic acid) composites
    Yamaji, Shusaku
    Kobayashi, Satoshi
    ADVANCED COMPOSITE MATERIALS, 2013, 22 (01) : 1 - 11
  • [29] Effect of N,N′-diallyl-phenylphosphoricdiamide on ease of ignition, thermal decomposition behavior and mechanical properties of poly (lactic acid)
    Zhao, Xiaomin
    de Juan, Sergio
    Reyes Guerrero, Francisco
    Li, Zhi
    Llorca, Javier
    Wang, De-Yi
    POLYMER DEGRADATION AND STABILITY, 2016, 127 : 2 - 10
  • [30] Degradation of composite materials composed of tricalcium phosphate and a new type of block polyester containing a poly(L-lactic acid) segment
    Imai, Y
    Nagai, M
    Watanabe, M
    JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 1999, 10 (04) : 421 - 432