Programming of synthetic regulatory DNA for cell-type targeting in humans

被引：0
作者：
Ventimiglia, Leandro N. [1 ]
Zelezniak, Aleksej [1 ,2 ,3 ]
机构：
[1] Kings Coll London, Randall Ctr Cell & Mol Biophys, New Hunts House,Guys Campus, London SE1 1UL, England
[2] Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41296 Gothenburg, Sweden
[3] Vilnius Univ, Inst Biotechnol, Life Sci Ctr, Sauletekio Al 7, LT-10257 Vilnius, Lithuania
来源：
MOLECULAR CELL | 2025年 / 85卷 / 02期
基金：
英国生物技术与生命科学研究理事会; 瑞典研究理事会;
关键词：
GENOME;
D O I：
10.1016/j.molcel.2024.12.019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In a recent study in Nature, Gosai et al.1 introduce a framework to engineer and validate synthetic DNA regulatory elements showing cell-type-specific activity in human cell lines, closing the distance to the machine- driven design of functional regulatory sequences with therapeutic applications in humans.
引用
收藏
页码：205 / 207
页数：3
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