Social Determinants of 6-Mercaptopurine Adherence Among Patients with Acute Lymphoblastic Leukemia/Lymphoma: A Cross-Sectional Analysis

被引：0
作者：
El-khatib, Ayah [1 ,2 ]
Matos, Kevin [3 ]
Rossoff, Jenna [1 ,2 ]
Psihogios, Alexandra [2 ,3 ]
机构：
[1] Ann & Robert H Lurie Childrens Hosp Chicago, Div Hematol Oncol & Stem Cell Transplant, 225 E Chicago Ave, Box 30, Chicago, IL 60611 USA
[2] Northwestern Univ, Feinberg Sch Med, Dept Pediat, Chicago, IL USA
[3] Northwestern Feinberg Sch Med, Dept Med Social Sci, Chicago, IL USA
来源：
JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY | 2024年
基金：
美国国家卫生研究院;
关键词：
Social determinants; race/ethnicity; insurance; ADI; adherence; PEDIATRIC CANCER; 6MP ADHERENCE; LEUKEMIA; DISADVANTAGE; CHILDREN;
D O I：
10.1089/jayao.2024.0119
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Acute lymphoblastic leukemia requires around 18 months of daily oral chemotherapy called 6-mercaptopurine (6-MP) for treatment. Previous research has included a broad age range and shows adolescent/young adult (AYA) age and minoritized race/ethnicity are associated with lower adherence. Few studies have evaluated how these intersecting identities impact adherence. In a retrospective analysis of an AYA sample, we evaluated the relationships between race/ethnicity, area deprivation index (ADI), and insurance with electronically monitored 6-MP adherence. Results showed minoritized race/ethnicity and ADI correlated with adherence. Findings highlight the need for equitable interventions that enhance adherence and improve outcomes among AYAs.
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页数：5
相关论文
共 20 条
[1]  
aardexgroup, Medication Adherence Software | AARDEX Group
[2]   Association of area deprivation index (ADI) with demographics and postoperative outcomes in pediatric brain tumor patients [J].
Aguirre, Alexander O. ;
Lim, Jaims ;
Baig, Ammad A. ;
Ruggiero, Nicco ;
Siddiqi, Manhal ;
Recker, Matthew J. ;
Li, Veetai ;
Reynolds, Renee M. .
CHILDS NERVOUS SYSTEM, 2024, 40 (01) :79-86
[3]  
[Anonymous], 2019, When Talking About Social Determinants, Precision Matters, DOI [10.1377/forefront.20191025.776011/full/cited2024Jul2, DOI 10.1377/FOREFRONT.20191025.776011/FULL/CITED2024JUL2]
[4]  
[Anonymous], Healthy People 2030
[5]  
[Anonymous], 2023, The Area Deprivation Index Is The Most Scientifically Validated Social Exposome Tool Available For Policies Advancing Health Equity Internet, DOI [10.1377/forefront.20230714.676093/full/cited2024Jul2, DOI 10.1377/FOREFRONT.20230714.676093/FULL/CITED2024JUL2]
[6]  
Beauchemin MP., 2023, JCO Oncology Prac, V19, P281, DOI [10.1200/OP.2023.19.11_suppl.281, DOI 10.1200/OP.2023.19.11_SUPPL.281]
[7]   A randomized trial of a mercaptopurine (6MP) adherence-enhancing intervention in children with acute lymphoblastic leukemia (ALL): A COG ACCL1033 study. [J].
Bhatia, Smita ;
Hageman, Lindsey ;
Chen, Yanjun ;
Wong, Florence Lennie ;
Mascarenhas, Leo ;
Freyer, David Robert ;
Mba, Nkechi ;
Aristizabal, Paula ;
Walterhouse, David ;
Lew, Glen ;
Kempert, Pamela ;
Russell, Thomas ;
McNall-Knapp, Rene ;
Jacobs, Shana S. ;
Dang, Ha ;
Raetz, Elizabeth A. ;
Relling, Mary V. ;
Landier, Wendy .
JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
[8]   6MP adherence in a multiracial cohort of children with acute lymphoblastic leukemia: a Children's Oncology Group study [J].
Bhatia, Smita ;
Landier, Wendy ;
Hageman, Lindsey ;
Kim, Heeyoung ;
Chen, Yanjun ;
Crews, Kristine R. ;
Evans, William E. ;
Bostrom, Bruce ;
Casillas, Jacqueline ;
Dickens, David S. ;
Maloney, Kelly W. ;
Neglia, Joseph P. ;
Ravindranath, Yaddanapudi ;
Ritchey, A. Kim ;
Wong, F. Lennie ;
Relling, Mary V. .
BLOOD, 2014, 124 (15) :2345-2353
[9]   Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia [J].
Harvey, Richard C. ;
Mullighan, Charles G. ;
Chen, I-Ming ;
Wharton, Walker ;
Mikhail, Fady M. ;
Carroll, Andrew J. ;
Kang, Huining ;
Liu, Wei ;
Dobbin, Kevin K. ;
Smith, Malcolm A. ;
Carroll, William L. ;
Devidas, Meenakshi ;
Bowman, W. Paul ;
Camitta, Bruce M. ;
Reaman, Gregory H. ;
Hunger, Stephen P. ;
Downing, James R. ;
Willman, Cheryl L. .
BLOOD, 2010, 115 (26) :5312-5321
[10]   Making Neighborhood-Disadvantage Metrics Accessible - The Neighborhood Atlas [J].
Kind, Amy J. H. ;
Buckingham, William R. .
NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (26) :2456-2458
12