2-Methylpropan-2-ammonium [(3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-heptanoate

被引：0
作者：
Grosu, Ioana-Georgeta [1 ]
Turza, Alexandru [1 ]
Filip, Xenia [1 ]
Miclaus, Maria-Olimpia [1 ]
机构：
[1] Natl Inst R&D Isotop & Mol Technol, 67-103 Donat, Cluj Napoca 400293, Romania
来源：
MOLBANK | 2024年 / 2024卷 / 03期
关键词：
pravastatin; statin; crystal structure; salt; FORMULATIONS; PRAVASTATIN; DELIVERY;
D O I：
10.3390/M1885
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pravastatin is a popular statin agent with applications in the treatment of cardiovascular diseases for patients with an abnormal lipid panel. The starting form of pravastatin is amorphous and following recrystallization, it becomes a crystalline solid with tert-butylamine salt molecules embedded within the lattice. Its molecular and crystal structure were elucidated based on single-crystal X-ray diffraction and characterized by ss-NMR.
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页数：6
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