2-Methylpropan-2-ammonium [(3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-heptanoate

被引：0

作者：

Grosu, Ioana-Georgeta ^{[1
]}

Turza, Alexandru ^{[1
]}

Filip, Xenia ^{[1
]}

Miclaus, Maria-Olimpia ^{[1
]}

机构：

[1] Natl Inst R&D Isotop & Mol Technol, 67-103 Donat, Cluj Napoca 400293, Romania

来源：

MOLBANK | 2024年 / 2024卷 / 03期

关键词：

pravastatin; statin; crystal structure; salt; FORMULATIONS; PRAVASTATIN; DELIVERY;

D O I：

10.3390/M1885

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pravastatin is a popular statin agent with applications in the treatment of cardiovascular diseases for patients with an abnormal lipid panel. The starting form of pravastatin is amorphous and following recrystallization, it becomes a crystalline solid with tert-butylamine salt molecules embedded within the lattice. Its molecular and crystal structure were elucidated based on single-crystal X-ray diffraction and characterized by ss-NMR.

引用

页数：6

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