Prevalence and sequelae of asymptomatic Clostridioides difficile colonization in children with inflammatory bowel disease

被引：2

作者：

Reasoner, Seth A. ^{[1
]}

Zhang, Lisa S. ^{[2
]}

Bernard, Rachel ^{[2
,5
]}

Edwards, Kathryn M. ^{[3
]}

Nicholson, Maribeth R. ^{[2
,4
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Pathol Microbiol & Immunol, Div Mol Pathogenesis, Nashville, TN USA

[2] Monroe Carell Jr Childrens Hosp Vanderbilt, Dept Pediat, Div Pediat Gastroenterol Hepatol & Nutr, Nashville, TN USA

[3] Monroe Carell Jr Childrens Hosp Vanderbilt, Dept Pediat, Div Pediat Infect Dis, Nashville, TN USA

[4] Vanderbilt Univ, Med Ctr, Vanderbilt Inst Infect Immunol & Inflammat, Nashville, TN USA

[5] Ochsner Hlth, Baton Rouge, LA USA

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2025年 / 80卷 / 03期

基金：

美国国家卫生研究院;

关键词：

carriage; outcomes; pediatrics; INFECTION; CARRIAGE;

D O I：

10.1002/jpn3.12439

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Colonization by Clostridioides difficile is common in children with inflammatory bowel disease (IBD) and complicates both the management of IBD and the diagnosis of C. difficile infection (CDI). There is a paucity of data on rates, risk factors, and outcomes associated with asymptomatic C. difficile colonization in children with IBD. We enrolled and prospectively followed 87 children with IBD without acute gastrointestinal symptoms. Twelve patients (13.8%) tested positive for C. difficile and were considered to have asymptomatic colonization. Elevated white blood cell count was associated with C. difficile colonization based on univariate regression. Three of the 12 (25%) C. difficile colonized patients were diagnosed with CDI in the 90 days following screening for C. difficile, versus 0 of the 75 who tested negative for C. difficile (p = 0.002). This data set the stage for further longitudinal tracking of children with IBD for C. difficile colonization and associated outcomes.

引用

页码：446 / 449

页数：4

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