Jun, an Oncological Foe or Friend?

被引：0
作者：
Jafri, Zuhayr [1 ]
Li, Yue [1 ]
Zhang, Jingwen [1 ]
O'Meara, Connor H. [1 ,2 ,3 ]
Khachigian, Levon M. [1 ]
机构：
[1] Univ New South Wales, Fac Med & Hlth, Sch Biomed Sci, Vasc Biol & Translat Res,Dept Pathol, Sydney, NSW 2052, Australia
[2] Univ Virginia Hlth Serv, Dept Otolaryngol Head & Neck Surg, Div Head & Neck Oncol & Microvascular Reconstruct, Charlottesville, VA 22903 USA
[3] Australian Natl Univ, Dept Otolaryngol Head & Neck Surg, Acton, ACT 0200, Australia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2025年 / 26卷 / 02期
基金：
英国医学研究理事会;
关键词：
Jun; AP1; transcription factor; cancer; N-TERMINAL KINASE; C-JUN; TRANSCRIPTION FACTOR; TUMOR MICROENVIRONMENT; INDUCED APOPTOSIS; ADVANCED MELANOMA; SUPPRESSOR-CELLS; BREAST-CANCER; ACTIVATION; PATHWAY;
D O I：
10.3390/ijms26020555
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Jun/JUN is a basic leucine zipper (bZIP) protein and a prototypic member of the activator protein-1 (AP-1) family of transcription factors that can act as homo- or heterodimers, interact with DNA elements and co-factors, and regulate gene transcription. Jun is expressed by both immune and inflammatory cells. Jun is traditionally seen as an oncoprotein that regulates processes involved in transformation and oncogenesis in human tumours. This article examines the traditional view that Jun plays a permissive role in cancer development and progression, whilst exploring emerging evidence supporting Jun's potential to prevent immune cell exhaustion and promote anti-tumour efficacy.
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页数：15
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共 112 条
  • [1] The tumour microenvironment as a target for chemoprevention
    Albini, Adriana
    Sporn, Michael B.
    [J]. NATURE REVIEWS CANCER, 2007, 7 (02) : 139 - 147
  • [2] An overview on liposarcoma subtypes: Genetic alterations and recent advances in therapeutic strategies
    Anju, M. S.
    Chandramohan, K.
    Bhargavan, Rexeena V.
    Somanathan, Thara
    Subhadradevi, Lakshmi
    [J]. JOURNAL OF MOLECULAR HISTOLOGY, 2024, 55 (03) : 227 - 240
  • [3] AP-1 Transcription Factors as Regulators of Immune Responses in Cancer
    Atsaves, Vasileios
    Leventaki, Vasiliki
    Rassidakis, George Z.
    Claret, Francois X.
    [J]. CANCERS, 2019, 11 (07)
  • [4] Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses
    Bayerl, Felix
    Meiser, Philippa
    Donakonda, Sainitin
    Hirschberger, Anna
    Lacher, Sebastian B.
    Pedde, Anna-Marie
    Hermann, Chris D.
    Elewaut, Anais
    Knolle, Moritz
    Ramsauer, Lukas
    Rudolph, Thomas J.
    Grassmann, Simon
    Oellinger, Rupert
    Kirchhammer, Nicole
    Trefny, Marcel
    Anton, Martina
    Wohlleber, Dirk
    Hoechst, Bastian
    Zaremba, Anne
    Krueger, Achim
    Rad, Roland
    Obenauf, Anna C.
    Schadendorf, Dirk
    Zippelius, Alfred
    Buchholz, Veit R.
    Schraml, Barbara U.
    Boettcher, Jan P.
    [J]. IMMUNITY, 2023, 56 (06) : 1341 - +
  • [5] Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness
    Berthenet, Kevin
    Ferrer, Camila Castillo
    Fanfone, Deborah
    Popgeorgiev, Nikolay
    Neves, David
    Bertolino, Philippe
    Gibert, Benjamin
    Hernandez-Vargas, Hector
    Ichim, Gabriel
    [J]. CELL REPORTS, 2020, 31 (10):
  • [6] Defining 'T cell exhaustion'
    Blank, Christian U.
    Haining, W. Nicholas
    Held, Werner
    Hogan, Patrick G.
    Kallies, Axel
    Lugli, Enrico
    Lynn, Rachel C.
    Philip, Mary
    Rao, Anjana
    Restifo, Nicholas P.
    Schietinger, Andrea
    Schumacher, Ton N.
    Schwartzberg, Pamela L.
    Sharpe, Arlene H.
    Speiser, Daniel E.
    Wherry, E. John
    Youngblood, Benjamin A.
    Zehn, Dietmar
    [J]. NATURE REVIEWS IMMUNOLOGY, 2019, 19 (11) : 665 - 674
  • [7] Induction of apoptosis by the transcription factor c-Jun
    BossyWetzel, E
    Bakiri, L
    Yaniv, M
    [J]. EMBO JOURNAL, 1997, 16 (07) : 1695 - 1709
  • [8] Selective antagonism of cJun for cancer therapy
    Brennan, Andrew
    Leech, James T.
    Kad, Neil M.
    Mason, Jody M.
    [J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2020, 39 (01)
  • [9] Colony-stimulating factor-1-induced AIF1 expression in tumor-associated macrophages enhances the progression of hepatocellular carcinoma
    Cai, Hao
    Zhu, Xiao-Dong
    Ao, Jian-Yang
    Ye, Bo-Gen
    Zhang, Yuan-Yuan
    Chai, Zong-Tao
    Wang, Cheng-Hao
    Shi, Wen-Kai
    Cao, Man-qing
    Li, Xiao-Long
    Sun, Hui-Chuan
    [J]. ONCOIMMUNOLOGY, 2017, 6 (09):
  • [10] Melanoma protective antitumor immunity activated by catalytic DNA
    Cai, Hong
    Cho, Eun-Ae
    Li, Yue
    Sockler, Jim
    Parish, Christopher R.
    Chong, Beng H.
    Edwards, Jarem
    Dodds, Tristan J.
    Ferguson, Peter M.
    Wilmott, James S.
    Scolyer, Richard A.
    Halliday, Gary M.
    Khachigian, Levon M.
    [J]. ONCOGENE, 2018, 37 (37) : 5115 - 5126
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