Seven New Aconitine-Type Diterpenoid Alkaloids from the Roots of Aconitum apetalum

被引：0

作者：

Luo, Yan-Yan ^{[1
,2
]}

Xu, Jin-Bu ^{[1
]}

Huang, Shuai ^{[1
]}

Zhou, Xian-Li ^{[1
,2
]}

机构：

[1] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Sichuan, Peoples R China

[2] Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Chengdu 610031, Sichuan, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2025年 / 22卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Aconitum apetalum; Aconitine-type; Diterpenoid alkaloids; Apetaldines K-Q; 2-(E)-(2-methylbut-2-enamido)benzoate moiety; C-19-DITERPENOID ALKALOIDS;

D O I：

10.1002/cbdv.202402055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven new aconitine-type C19-diterpenoid alkaloids, apetaldines K-Q (1-7), were isolated from the roots of Aconitum apetalum (Huth) B. Fedtsch. Their structures were established on the basis of extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR). Among them, compounds 1 and 2 possess a unique 2-(E)-(2-methylbut-2-enamido)benzoate moiety at the C-18 position. Furthermore, cytotoxic activities of these diterpenoid alkaloids were also evaluated.

引用

页数：8

共 17 条

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