Platelet-mimicking nanoparticles loaded with diallyl trisulfide for Mitigating Myocardial Ischemia-Reperfusion Injury in rats

被引：0

作者：

Chen, Yihan ^{[1
,2
]}

Lin, Ling ^{[2
,3
]}

Xu, Lingling ^{[2
,4
,5
]}

Jin, Qiaofeng ^{[2
,4
,5
]}

Fu, Wenpei ^{[2
,4
,5
]}

Bai, Ying ^{[2
,4
,5
]}

Huang, Tian ^{[2
,4
,5
]}

Gao, Tang ^{[2
,4
,5
]}

Wu, Wenqian ^{[2
,4
,5
]}

Xu, Chunyan ^{[2
,4
,5
]}

Wang, Jing ^{[2
,4
,5
]}

Zhang, Li ^{[2
,4
,5
,6
]}

Lv, Qing ^{[2
,4
,5
]}

Yang, Yali ^{[2
,4
,5
]}

Xie, Mingxing ^{[2
,4
,5
,6
]}

Dong, Xiaoqiu ^{[1
]}

机构：

[1] Harbin Med Univ, Dept Ultrasonog, Affiliated Hosp 4, Harbin, Peoples R China

[2] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Ultrasound Med, Wuhan, Peoples R China

[3] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Diagnost Ultrasound & Echocardiog, Sch Med, Hangzhou, Peoples R China

[4] Clin Res Ctr Med Imaging Hubei Prov, Wuhan 430022, Peoples R China

[5] Hubei Prov Key Lab Mol Imaging, Wuhan 430022, Peoples R China

[6] Shenzhen Huazhong Univ Sci & Technol Res Inst, Shenzhen, Peoples R China

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2025年 / 248卷

基金：

中国国家自然科学基金;

关键词：

Mesoporous silica nanoparticles; Platelet membrane; Diallyl trisulfide; Hydrogen sulfide; Myocardial ischemia-reperfusion injury; RELEASE;

D O I：

10.1016/j.colsurfb.2024.114460

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Hydrogen sulfide (H2S) shows promise in treating myocardial ischemia-reperfusion injury (MIRI), but the challenge of controlled and sustained release hinders its clinical utility. In this study, we developed a platelet membrane-encapsulated mesoporous silica nanoparticle loaded with the H2S donor diallyl trisulfide (PM-MSNDATS). PM-MSN-DATS demonstrated optimal encapsulation efficiency and drug-loading content. Comprehensive in vitro and in vivo assessments confirmed the biosafety of PM-MSN-DATS. In vitro, PM-MSN-DATS adhered to inflammation-activated endothelial cells and exhibited targeted accumulation in MIRI rat hearts. In vivo experiments revealed significant reductions in reactive oxygen species (ROS) and myocardial fibrosis area, improving cardiac function. Our findings highlight successfully creating a targeted H2S delivery system through platelet membrane-coated MSN nanoparticles. This well-designed drug delivery platform holds significant promise for advancing MIRI treatment strategies.

引用

页数：11

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