Development of small-molecule NIR-II photothermal agents for image-guided tumor therapy

被引：3
作者：
He, Long [1 ,2 ]
Li, Yi [1 ]
Zhang, Chonghua [1 ]
Zhang, Xingxing [2 ]
Wang, Benhua [3 ]
Ren, Tianbing [2 ]
Yuan, Lin [2 ]
机构：
[1] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Theoret Organ Chem & Funct Mol, Minist Educ, Xiangtan 411201, Peoples R China
[2] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China
[3] Cent South Univ, Coll Chem & Chem Engn, Key Lab Hunan Prov Water Environm & Agr Prod Safet, Changsha 410083, Peoples R China
来源：
COORDINATION CHEMISTRY REVIEWS | 2025年 / 533卷
基金：
中国国家自然科学基金;
关键词：
Small molecule photothermal agents; NIR-II imaging; Photothermal therapy; Photothermal conversion efficiency; Cancer therapy; CYANINE DYE; NANOPARTICLES; PHOTOTHERANOSTICS; FLUOROPHORE; INTEGRIN; SURGERY; POLYMER;
D O I：
10.1016/j.ccr.2025.216549
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Small-molecule photothermal agents (PTAs) working in second near-infrared (NIR-II) region exhibited a great potential of cancer treatment and diagnosis for the advantages of minimal side effect, deeper penetration ability of tissue, and easily adjustable of structure. Various small-molecule PTA that integrate NIR-II fluorescence/ photoacoustic (PA) imaging and thermal effect can visualize tumor locations and thermally irradiate tumor in real time, holding significant potential for early diagnosis and precision treatment of cancer. In this review, we summarize various strategies to improve the photothermal therapy (PTT) effects of small-molecule PTAs for NIRII imaging-guided cancer treatment, including the enhancement of photothermal conversion efficiency (PCE) and photostability, the improvement of biocompatibility and specificity, and the facilitation of PTT by synergistic therapy. The perspectives and obstacles associated with NIR-II small-molecule PTAs for application are also discussed.
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页数：46
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